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Current anthrax vaccines for human use have limitations including undefined components, limited mucosal immunity, and suboptimal adjuvant delivery. This study introduces 2 polymers, MP1 and MP2, each containing disulfide bonds. MP1 incorporates tertiary amines to induce proton sponge effect, while MP2 features terminal phenylboronic acid moieties for protein conjugation. Nanoparticle vaccine YM1.7 is created through self\u2010assembly of MP1, MP2, and STING agonist MSA\u20102, followed by N\u2500B coordination of recombinant protein antigen (rPA) on its surface. When administered via aerosolized intratracheal inoculation into the lung, YM1.7 is internalized by antigen\u2010presenting cell\u00a0and trafficked to the lysosome, where acidic environment dissociates N\u2500B bond, releasing rPA for antigen presentation. Proton sponge effect allows nanoparticle to escape into the cytosol, and then disulfide bond cleavage triggered by cytosolic glutathione\u00a0causes dissociation of nanoparticle and release of MSA\u20102 within the cytosol, significantly enhancing bioavailability of MSA\u20102 as an adjuvant. This spatiotemporal delivery mechanism elicits a coordinated innate, humoral, mucosal, and cell\u2010mediated immune response in mice, providing strong protection against inhalational anthrax. Given its modular design nature, YM1.7 represents a promising platform for developing next\u2010generation mucosal vaccines against infections and cancers.\n                  <\/jats:p>","DOI":"10.1002\/adma.202512910","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T08:26:46Z","timestamp":1776673606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cytosol\u2010Targeting Delivery of Non\u2010Nucleotide STING Agonist Achieves Inhalable Nanoparticle\u2010Based Anthrax Vaccine"],"prefix":"10.1002","volume":"38","author":[{"given":"Xi","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Animal Science and Veterinary Medicine Shenyang Agricultural University  Shenyang China"},{"name":"State Key Laboratory of Pathogen and Biosecurity Academy of Military Medical Sciences  Beijing 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