{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:58:28Z","timestamp":1781513908276,"version":"3.54.1"},"reference-count":104,"publisher":"Wiley","issue":"28","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Conformational transitions of neuroproteins are closely associated with neurological disorders and represent key biomarkers for diagnosis and disease monitoring. A reliable and label\u2010free method for detecting and tracking these structural changes is critical for effective clinical application. In this work, a galvanic molecular entrapment (GME) strategy is presented to combine with surface\u2010enhanced Raman scattering (SERS) for localization and label\u2010free detection of neuroproteins. This approach integrates galvanic replacement with in situ Au surface growth to enable precise molecular entrapment and plasmonic hotspot formation directly around target analytes. Such spatial confinement optimizes analyte positioning within the electromagnetic field, thereby enhancing SERS signal intensity and overcoming geometric mismatches that typically limit sensitivity. The GME method successfully profiled neuroprotein conformational states and demonstrated strong potential for proteomic analysis. A logistic regression model applied to the spectral dataset enabled accurate classification of saliva samples from individuals with epilepsy, schizophrenia, Parkinson's disease, and healthy controls, achieving high sensitivity, specificity, and diagnostic accuracy. This integrated platform offers a non\u2010invasive tool for neurological diagnostics and holds significant promise for advancing personalized healthcare in the management of neurological disorders.<\/jats:p>","DOI":"10.1002\/adma.202513500","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T07:16:49Z","timestamp":1769325409000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Label\u2010Free SERS Fingerprinting of Neuroprotein Conformational Dynamics in Human Saliva"],"prefix":"10.1002","volume":"38","author":[{"given":"Muhammad Shalahuddin Al","family":"Ja'farawy","sequence":"first","affiliation":[{"name":"Advanced Bio and Healthcare Materials Research Division Korea Institute of Materials Science (KIMS)  Changwon Gyeongnam 51508 South Korea"},{"name":"Advanced Materials Engineering Korea National University of Science and Technology (UST)  Daejeon 34113 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Yeong","family":"Yang","sequence":"additional","affiliation":[{"name":"Advanced Bio and Healthcare Materials Research Division Korea Institute of Materials Science (KIMS)  Changwon Gyeongnam 51508 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaewon","family":"Mun","sequence":"additional","affiliation":[{"name":"Advanced Bio and Healthcare Materials Research Division Korea Institute of Materials Science (KIMS)  Changwon Gyeongnam 51508 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghun","family":"Lee","sequence":"additional","affiliation":[{"name":"Advanced Bio and Healthcare Materials Research Division Korea Institute of Materials Science (KIMS)  Changwon Gyeongnam 51508 South Korea"},{"name":"Advanced Materials Engineering Korea National University of Science and Technology (UST)  Daejeon 34113 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Bum","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery St. Vincent's Hospital College of Medicine The Catholic University of Korea Seoul 16247 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo Hyun","family":"Um","sequence":"additional","affiliation":[{"name":"Department of Psychiatry St. Vincent's Hospital College of Medicine The Catholic University of Korea Seoul 16247 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Advanced Bio and Healthcare Materials Research Division Korea Institute of Materials Science (KIMS)  Changwon Gyeongnam 51508 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Gyu","family":"Park","sequence":"additional","affiliation":[{"name":"Advanced Bio and Healthcare Materials Research Division Korea Institute of Materials Science (KIMS)  Changwon Gyeongnam 51508 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Advanced Bio and Healthcare Materials Research Division Korea Institute of Materials Science (KIMS)  Changwon Gyeongnam 51508 South Korea"},{"name":"Advanced Materials Engineering Korea National University of Science and Technology (UST)  Daejeon 34113 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Ho","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery St. Vincent's Hospital College of Medicine The Catholic University of Korea Seoul 16247 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1776-1802","authenticated-orcid":false,"given":"Ho Sang","family":"Jung","sequence":"additional","affiliation":[{"name":"Advanced Bio and Healthcare Materials Research Division Korea Institute of Materials Science (KIMS)  Changwon Gyeongnam 51508 South Korea"},{"name":"Advanced Materials Engineering Korea National University of Science and Technology (UST)  Daejeon 34113 South Korea"},{"name":"School of Biomedical Engineering Korea University  Seoul 02481 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,24]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.032"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01382-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0244-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-0333-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23908"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2024.116128"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c00048"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt185"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/05704928.2023.2181818"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b04224"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00238F"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00265"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2020.112825"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.4c00083"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.7b02338"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13615-2"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano9050792"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtchem.2025.102765"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gce.2023.07.004"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtchem.2023.101513"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2023.115775"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2024.175198"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42943-7"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201202370"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA13426A"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2024.135828"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/j150508a015"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11468-011-9253-0"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2018.10.054"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01500a060"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja305245g"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm402384j"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/j100085a030"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/j150667a013"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jchemed.3c00634"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01936a002"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201302820"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.6b00393"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TC02163J"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5348"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja993622x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2011.11.025"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja513205s"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.susc.2019.121529"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34749-w"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2018.10.025"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja905725n"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16865-6"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.7b08785"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz7949"},{"key":"e_1_2_8_51_1","first-page":"80","volume":"52","author":"Silkstone R. S.","year":"2012","journal-title":"Biol. Med."},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200800255"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JNP.9.093796"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep13793"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi025571d"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB00983D"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.6b10905"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202102337"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25112498"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.3c02662"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b05837"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CP01276J"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25051195"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.3402\/nano.v2i0.6032"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-023-00651-2"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.2217\/17520363.2.4.363"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3NR06365H"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.4c00097"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2012460117"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/agm2.12282"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-019-00168-1"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20230599"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.878869"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2021.339074"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA00870F"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios13010027"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1087753"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-021-00505-9"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11126-017-9507-x"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.202400031"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2017.10.010"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.3.398"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2023.115779"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.9b00460"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology9060122"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcae451"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-00967-z"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17186"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.5.867"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04418-8"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.135540"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-022-02567-5"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2010.02.005"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.3713"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0687-6"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2022.102270"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00112"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10436-6"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-023-00896-x"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.748599"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2025.1570553"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2025.107614"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjment-2024-301017"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbac135"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202513500","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202513500","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202513500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:45:03Z","timestamp":1781513103000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202513500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,24]]},"references-count":104,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/adma.202513500"],"URL":"https:\/\/doi.org\/10.1002\/adma.202513500","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,24]]},"assertion":[{"value":"2025-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13500"}}