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Herein, a PEGylated amorphous BiOI (a\u2010BiOI@PEG) nanoenzyme is developed, whose abundant unsaturated bonds, iodine\u2010containing delivery systems, and reduced bandgap facilitate active\/passive uptake by thyroid cancer cells and response to second near\u2010infrared (NIR\u2010II), respectively. This allows for accurate DTC\u2010specific targeting of tumor cells for ultrasound and computer tomography (CT) imaging and enhances synergistic phototherapy. Consequently, the results show that a\u2010BiOI@PEG outperforms the common CT contrast agent iohexol and B\u2010mode ultrasonography. This process is followed by the generation of remarkable ROS and an increase in temperatures above 48\u00a0\u2103 in 10\u00a0min under 1064\u00a0nm NIR, inducing impressive immunogenic cell death and exerting long\u2010term anti\u2010tumor effects at primary and metastatic sites to prevent cancer metastasis, while normal cells are rarely killed. This study reveals the intricate relationship between amorphous structures and diagnostic integration, laying the foundation for the design of highly targeted and efficient amorphous nanoenzymes that simultaneously target thyroid tumors.<\/jats:p>","DOI":"10.1002\/adma.202514116","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:57:57Z","timestamp":1763369877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Amorphous A\u2010BiOI@PEG Nanoenzyme Targets Imaging and Synergistic Phototherapy in Differentiated Thyroid Cancer"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3556-2719","authenticated-orcid":false,"given":"Chen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery Peking University People's Hospital Beijing 100044 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