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Herein, enantiomeric and twisted octahedron silver nanoclusters (D\u2010\/L\u2010Ag\n                    <jats:sub>6<\/jats:sub>\n                    SP\n                    <jats:sub>6<\/jats:sub>\n                    ), featuring bichirality at both the molecular and nanoscopic scales, are designed and synthesized by employing a chiral bidentate ligand of thiazolethione enantiomer (D\u2010 or L\u20104\u2010phenylthiazolidine\u20102\u2010thione, abbreviated as D\u2010SP or L\u2010SP) in conjunction with silver acetate. The resulting nanoclusters are further modified with PEG\n                    <jats:sub>2000<\/jats:sub>\n                    to produce water\u2010dispersible D\u2010Ag\n                    <jats:sub>6<\/jats:sub>\n                    SP\n                    <jats:sub>6<\/jats:sub>\n                    @PEG and L\u2010Ag\n                    <jats:sub>6<\/jats:sub>\n                    SP\n                    <jats:sub>6<\/jats:sub>\n                    @PEG nanoparticles, enabling enantioselective recognition and quantitative determination of various biothiols in plasma through circular dichroism measurements. The study also elucidates the bichiral recognition and determination of biothiols through a ligand\u2010induced disassembly\u2010assembly mechanism. Both D\u2010 and L\u2010type Ag\n                    <jats:sub>6<\/jats:sub>\n                    SP\n                    <jats:sub>6<\/jats:sub>\n                    @PEG nanoparticles demonstrate excellent anti\u2010interference properties for discriminating biothiols using principal component analysis. The bichirality of nanoclusters shows high enantioselectivity in chiral recognition of biothiols and their corresponding enantiomers. This work not only provides a convenient strategy for bichiral recognition and quantitative determination of biothiols in plasma, but also holds promise for developing hierarchically chiral nanomaterials applicable in biomedical engineering, nanomedicine, and drug screening.\n                  <\/jats:p>","DOI":"10.1002\/adma.202514158","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T12:19:33Z","timestamp":1759148373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Biomimetic Chiral Recognition of Biothiols by Enantiomeric Nanoclusters in Plasma"],"prefix":"10.1002","volume":"38","author":[{"given":"Xuejuan","family":"Wang","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Chemical Assessment and Sustainability School of Chemical Science and Engineering Advanced Research Institute Tongji University  Shanghai 200092 P. R. 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