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Current therapeutic strategies remain insufficient to address these pathological features and restore physiological homeostasis. Here, a dual\u2010duty nanomedicine (MAC@EGCG\u2010Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    ), engineered with an inflammation\u2010homing M2\u2010type macrophage membrane \u201cshell\u201d is rationally designed and developed, which encapsulates silk fibroin nanocages loading with epigallocatechin gallate (EGCG) and ferromagnetic nanoparticles (Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    ). Upon intraperitoneal injection and exposure to an alternating magnetic field (AMF), the nanomedicine selectively accumulated in inflamed lesions, enabling site\u2010specific therapeutic effects. Controlled AMF irradiation provided localized mild hyperthermia and reductive EGCG for UC treatment or hyperpyrexia and oxidative EGCG for treating CAC. Moreover, this therapeutic strategy reprogrammed colonic immune responses, restored mucosal integrity, alleviated iron deficiency, and modulated microbiota and its metabolites. The study highlights the therapeutic potential of a single pathology\u2010driven nanomedicine against both UC and CAC through AMF manipulation.\n                  <\/jats:p>","DOI":"10.1002\/adma.202514413","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T07:36:18Z","timestamp":1762846578000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pathology\u2010Driven Design of a Biomimetic Ferromagnetic Nanomedicine for Dual\u2010Mode Treatment of Ulcerative Colitis and Colitis\u2010Associated Colorectal Cancer"],"prefix":"10.1002","volume":"38","author":[{"given":"Shengsheng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pharmacy Personalized Drug Research and Therapy Key Laboratory of Sichuan Province Sichuan Academy of Medical Sciences &amp; Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China  Chengdu 610054 China"},{"name":"State Key Laboratory of Resource Insects College of Sericulture Textile, and Biomass Sciences, Southwest University  Chongqing 400715 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Personalized Drug Research and Therapy Key Laboratory of Sichuan Province Sichuan Academy of Medical Sciences &amp; Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China  Chengdu 610054 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resource Insects College of Sericulture Textile, and Biomass Sciences, Southwest University  Chongqing 400715 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100190 China"},{"name":"Institutes of Biomedical Sciences Inner Mongolia University  Hohhot 010070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The Second Affiliated Hospital of Chongqing Medical University  Chongqing 400010 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"HIFU Tumor Treatment Center The Second Affiliated Hospital of Chongqing Medical University  Chongqing 400010 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Second Affiliated Hospital of Army Medical University (Xinqiao Hospital)  Chongqing 400037 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