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Traditional approaches, using exogenous electrical stimulation or electroactive materials, often fail to align with the endogenous iontronic bioelectricity of natural cartilage. Herein, an implantable mechano\u2010iontronic hydrogel (MI\u2010hydrogel) is biomimetically designed to enhance cartilage repair. This MI\u2010hydrogel generates iontronic electricity under deformation, closely mimicking the characteristics and mechanisms of natural cartilage. It is demonstrated that the MI\u2010hydrogel synergistically integrates iontronic electricity and mechanical stimulation during physical activity, activating the ion channel protein Piezo1. This activation promotes the chondrogenic differentiation of stem cells in vitro and facilitates cartilage repair in vivo. Additionally, these coupled effects are shown to reprogram the metabolic microenvironment, enhancing glutamine metabolism and accelerating the cartilage regeneration process. 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