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Herein, a multifunctional magnetically actuated microrobotic platform for targeted biopsy of deep\u2010seated micro\u2010lesion in lung for potential use of early lung cancer diagnosis is reported. This conical helix\u2010structured microrobot features controllable gold nanospike decoration at its tip, integrating dual functionality in drilling\u2010enabled tissue sampling and surface\u2010enhanced Raman scattering (SERS) biosensing. Utilizing real\u2010time tracheoscopy and fluoroscopy guidance, this platform achieves magnetic navigation through saline\u2010filled bronchi to target lesions, followed by on\u2010demand sampling and retrieval, whose feasibility is systematically verified through ex vivo porcine lung models and in vivo rabbit trials. The collected biomarker and tissue samples can be rapidly recognized and quantified based on SERS spectroscopy. Moreover, through establishing a convolutional neural network\u2010based deep learning model, it is succeed to distinguish between the healthy and various cancerous lung tissues from clinical patients, achieving a recognition accuracy of over 94.3% within just 3\u00a0min. Therefore, this work represents a microrobot\u2010based biopsy techniques for noninvasive and precise sampling in lung with diagnosis capability of early\u2010stage lung cancer, offering substantial improvements over conventional biopsy methods.<\/jats:p>","DOI":"10.1002\/adma.202514664","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T07:11:44Z","timestamp":1758611504000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Magnetic Microrobot With Drilling\u2010Sensing Dual Functionality for Targeted Biopsy of Deep\u2010Seated Tracheal Microlesions"],"prefix":"10.1002","volume":"38","author":[{"given":"Yong","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Clinical Laboratory Diagnostics ( Chinese Ministry of Education) College of Laboratory Medicine Chongqing Medical University Chongqing 400016 China"},{"name":"Sauvage Laboratory for Smart Materials School of Integrated Circuits Harbin Institute of Technology (Shenzhen)  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Jin","sequence":"additional","affiliation":[{"name":"Sauvage Laboratory for Smart Materials School of Integrated Circuits Harbin Institute of Technology (Shenzhen)  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Liu","sequence":"additional","affiliation":[{"name":"Sauvage Laboratory for Smart Materials School of Integrated Circuits Harbin Institute of Technology (Shenzhen)  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University  Xiamen 361005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyu","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Sensing Science and Engineering Shanghai Jiao Tong University  Shanghai 200240 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichang","family":"Guo","sequence":"additional","affiliation":[{"name":"Sauvage Laboratory for Smart Materials School of Integrated Circuits Harbin Institute of Technology (Shenzhen)  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University  Xiamen 361005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University  Xiamen 361005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering Southeast University (Jiulonghu Campus)  Nanjing 211189 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhong","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Clinical Laboratory Diagnostics ( Chinese Ministry of Education) College of Laboratory Medicine Chongqing Medical University Chongqing 400016 China"},{"name":"School of Sensing Science and Engineering Shanghai Jiao Tong University  Shanghai 200240 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2248-4806","authenticated-orcid":false,"given":"Xing","family":"Ma","sequence":"additional","affiliation":[{"name":"Sauvage Laboratory for Smart Materials School of Integrated Circuits Harbin Institute of Technology (Shenzhen)  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-017-1658-5"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001549"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-021-07089-w"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20190866"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims-22-474"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","unstructured":"H.Xu A.Lasso S.Vikal P.Guion A.Krieger A.Kaushal L. 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