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Traditional solutions separate glucose detection and insulin delivery, which is less efficient compared to emerging closed\u2010loop wearable systems controlled by continuous glucose monitors (CGMs). However, CGM\u2010controlled systems raise new safety risks, as false CGMs readings can cause insulin overdose, which results in hypoglycemia and fatal consequences. This work proposes a concept of a dual closed\u2010loop insulin delivery system (DuoLoop) to mitigate the risk issue of CGM\u2010controlled systems. The first closed\u2010loop is automated insulin delivery controlled by CGM. The second closed\u2010loop is the controlled release of glucose\u2010responsive insulin (GRI), whose release rate depends on actual glucose levels. A customized algorithm is trained and embedded into the wearable CGMs for edge computing. The DuoLoop system shows improved safety in preliminary in vivo test\u00a0(longer normoglycemia durations, 98.82% vs 92.10%), encouraging its deployment toward precision diabetes care.<\/jats:p>","DOI":"10.1002\/adma.202514945","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T14:36:41Z","timestamp":1768228601000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A Wearable, Dual Closed\u2010loop Insulin Delivery System for Precision Diabetes Management"],"prefix":"10.1002","volume":"38","author":[{"given":"Xuecheng","family":"He","sequence":"first","affiliation":[{"name":"Department of Electrical and Electronic Engineering The University of Hong Kong  Hong Kong SAR 999077 China"},{"name":"School of Biomedical Engineering The University of Hong Kong  Hong Kong SAR 999077 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