{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T22:31:55Z","timestamp":1788733915503,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22234005"],"award-info":[{"award-number":["22234005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22494632"],"award-info":[{"award-number":["22494632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22222407"],"award-info":[{"award-number":["22222407"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20222015"],"award-info":[{"award-number":["BK20222015"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Surface\u2010enhanced Raman spectroscopy (SERS) achieves ultrahigh sensitivity at the molecular level and enables water\u2010interference\u2010free detection. However, the development of single\u2010particle semiconductor substrates that do not rely on gap\u2010enhanced electromagnetic fields remains challenging. Herein,\u00a0capitalizing on the dual merits of morphology\u2010induced prolonged light accumulation and structure\u2010improved interfacial charge transfer, we developed an ultrasensitive semiconductor\u2010based individually SERS system based on a highly crystalline irregular hexagonal prism In\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    (I\u2010In\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    ) microcavity. Finite\u2010difference time\u2010domain simulations and photoluminescence spectra confirmed the successful establishment of a whispering\u2010gallery\u2010mode microcavity on the I\u2010In\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    platform. This microcavity enables the long\u2010term confinement and oscillation of resonant photons, thereby significantly enhancing light\u2013matter interactions. Aberration\u2010corrected electron microscopy demonstrated that although I\u2010In\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    single crystals were isostructural to regular hexagonal prisms, they exhibit contracted lattice parameters. Density functional theory calculations further revealed that atomic\u2010scale compressive lattice strain induces electronic band restructuring, enhancing the interfacial interactions between individual particle substrates and adsorbed molecules at the atomic level. In addition, the I\u2010In\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    SERS system demonstrates quantitative and multiplexing capabilities for rapid antibiotic detection. This work presents new perspectives for constructing supersensitive semiconductor SERS sensors using a micron\u2010scale single\u2010particle platform.\n                  <\/jats:p>","DOI":"10.1002\/adma.202515510","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T07:46:47Z","timestamp":1770018407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Individual Single\u2010Crystalline Irregular In\n                    <sub>2<\/sub>\n                    O\n                    <sub>3<\/sub>\n                    Microcavity for Ultrasensitive Semiconductor\u2010Based SERS Biosensor"],"prefix":"10.1002","volume":"38","author":[{"given":"Mengyang","family":"Zhang","sequence":"first","affiliation":[{"name":"Collaborative Innovation Center of Biomedical Functional Materials of Jiangsu Province School of Chemistry and Materials Science Nanjing Normal University  Nanjing China"},{"name":"School of Chemistry and Molecular Engineering Nanjing Tech University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Li","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Biomedical Functional Materials of Jiangsu Province School of Chemistry and Materials Science Nanjing Normal University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Materials\u2010Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Materials\u2010Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Biomedical Functional Materials of Jiangsu Province School of Chemistry and Materials Science Nanjing Normal University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyao","family":"Li","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Biomedical Functional Materials of Jiangsu Province School of Chemistry and Materials Science Nanjing Normal University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suli","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Engineering Nanjing Tech University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyin","family":"Wang","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Biomedical Functional Materials of Jiangsu Province School of Chemistry and Materials Science Nanjing Normal University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingsheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7049-7217","authenticated-orcid":false,"given":"Zhihui","family":"Dai","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Biomedical Functional Materials of Jiangsu Province School of Chemistry and Materials Science Nanjing Normal University  Nanjing China"},{"name":"School of Chemistry and Molecular Engineering Nanjing Tech University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41566-023-01264-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2048-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202308950"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2206990119"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c14502"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20795"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c04514"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42943-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c13240"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c01649"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.102140"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00670"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32261-9"},{"key":"e_1_2_8_15_1","first-page":"9214","article-title":"Plasmonic All\u2010Frame\u2010Faceted Octahedral Nanoframes with Eight Engraved Y\u2010Shaped Hot Zones","volume":"16","author":"Kim J.","year":"2022","journal-title":"Nano"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11829-y"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202005133"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202218055"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44160-025-00823-6"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c10107"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13505-7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15484-6"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c03205"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c10774"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202424986"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201705187"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202112367"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.1c05142"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202201799"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41566-025-01669-2"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202100453"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202204403"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4ee05232c"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/am4056358"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-017-1481-y"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202416878"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202419859"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202307584"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NH00450J"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202102893"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adom.202100143"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201700037"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58415-z"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202410509"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41893-025-01603-y"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202104555"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5c01814"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c01599"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c06854"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202515510","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202515510","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202515510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:30:36Z","timestamp":1773325836000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202515510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,1]]},"references-count":48,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/adma.202515510"],"URL":"https:\/\/doi.org\/10.1002\/adma.202515510","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,1]]},"assertion":[{"value":"2025-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15510"}}