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However, lethal cooling and warming remain a critical obstacle to cross\u2010scale cryopreservation of clinical biospecimens. Herein, a snowman\u2010like Janus nanohybrid composed of magnetic iron tetraoxide and photothermal polypyrrole is reported. Its cranial\u2013corporal asymmetry enables heterogeneous hydration for a record high efficiency of ice confinement, reducing mean ice crystal area by 98.4%. Molecular dynamics simulations reveal that Janus architecture simultaneously enhances interactions with ice and strengthens the local hydration anisotropy, accounting for the effective inhibition of ice growth. Superflash warming over 920\u00a0\u00b0C min\n                    <jats:sup>\u20121<\/jats:sup>\n                    by magnetically rotating its anisotropic structure for uniform heat dissipation narrows the hostile temperature window in micro\u2010\/macroscopic scenarios, as further confirmed by Monte Carlo modeling. This design enables cost\u2010effective post\u2010thaw magnetic retrieval, eliminating the need for heavy centrifuges, well\u2010suited for scalable and on\u2010site applications. As a result, cryopreserved samples from single cells, bacteria, to porcine trachea retain near\u2010complete viability and functionality. Therefore, this study offers a promising technique to bridge the gap between microscale cell storage and whole\u2010organ preservation.\n                  <\/jats:p>","DOI":"10.1002\/adma.202515996","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T08:06:06Z","timestamp":1764403566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Janus Nanohybrids Enable Superflash Warming and High\u2010Affinity Ice Confinement for Cross\u2010Scale Cryopreservation"],"prefix":"10.1002","volume":"38","author":[{"given":"Tao","family":"Ke","sequence":"first","affiliation":[{"name":"Institute of Biopharmaceutical and Health Engineering Shenzhen International Graduate School Key Laboratory of Active Proteins and Peptides Green Biomanufacturing of Guangdong Higher Education Institutes Tsinghua University  Shenzhen Guangdong 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Fan","sequence":"additional","affiliation":[{"name":"Institute of Biopharmaceutical and Health Engineering Shenzhen International Graduate School Key Laboratory of Active Proteins and Peptides Green Biomanufacturing of Guangdong Higher Education Institutes Tsinghua University  Shenzhen Guangdong 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Energy and Mechanical Engineering Nanjing Normal University  Nanjing Jiangsu 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Applied Radiation Institute Shanghai Key Laboratory of Atomic Control and Application of Inorganic 2D Supermaterials State Key Lab. 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