{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:57:26Z","timestamp":1791860246797,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52073015"],"award-info":[{"award-number":["52073015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Photoactivated cobalt(III) (Co(III)) complexes have great potential for cancer therapy due to their unique interactions with cancer cells. However, its clinical application remains limited by its high toxicity due to low spatial\u2010temporal control. Here, a second near\u2010infrared window (NIR\u2010II) photoactivated Co(III) nanoparticles (NanoCo) is shown. Under 1064\u00a0nm light irradiation, NanoCo is capable of generating photothermal heat to accelerate the reduction of Co(III) to Co(II). Under hypoxic conditions, NanoCo is 166 times more effective than cisplatin at killing platinum\u2010resistant A549DDP tumor cells. Notably, when exposed to 1064\u00a0nm irradiation, NanoCo becomes 5000 times more effective than oxaliplatin at killing CT26 cells under normoxic conditions. NanoCo accumulates at the tumor site, generating photothermal heat and killing tumor cells under 1064\u00a0nm irradiation. Additionally, NanoCo under 1064\u00a0nm irradiation triggers immunogenic cell death, further stimulating dendritic cell maturation and inducing anti\u2010tumor immune responses. The combination of Pt(IV) nanoparticles (HSA@Pt) with NanoCo under 1064\u00a0nm irradiation achieves a 99% tumor growth inhibition rate in a 4T1 tumor\u2010bearing mouse model. This work is the first to introduce Co(III) complexes activated by NIR\u2010II light for photoactivated chemo\u2010immunotherapy.<\/jats:p>","DOI":"10.1002\/adma.202516008","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T06:57:17Z","timestamp":1764831437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["NIR\u2010II Photoactivatable Cobalt(III) Nanoparticles for Photoactivated Metal Chemo\u2010Immunotherapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Dongsheng","family":"Tang","sequence":"first","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Laboratory of Polymer Physics and Chemistry Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhui","family":"Cui","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Laboratory of Polymer Physics and Chemistry Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Karges","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Biochemistry Ruhr\u2010University  44780 Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Xu","sequence":"additional","affiliation":[{"name":"Sydney Dental School, Faculty of Medicine and Health The University of Sydney  Camperdown NSW 2006 Australia"},{"name":"Charles Perkins Centre The University of Sydney  Camperdown NSW 2006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8159-8187","authenticated-orcid":false,"given":"Haihua","family":"Xiao","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Laboratory of Polymer Physics and Chemistry Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Peking University People's Hospital  Beijing 100044 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking University Third Hospital  Beijing 100191 P. R. China"},{"name":"Peking University Shenzhen Graduate School  Shenzhen 518055 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4291"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29572-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2918"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20250036"},{"key":"e_1_2_7_5_1","first-page":"519","volume":"20","author":"Masone M. C.","year":"2023","journal-title":"Nat. Rev. Urol."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00209"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00597"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C0DT00223B"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2019.07.099"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2012.11.019"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9DT01576K"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201502702"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.2c00150"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR3229"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.07.042"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5DT02101D"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm3014713"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-016-0008"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16993-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30721-w"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.34133\/cbsystems.0262"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4476"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-022-01468-y"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18051-1"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49409-4"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03505-4"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07752-y"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04003-2"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49156-6"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1593-5"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42399-9"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-024-00892-0"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic50030a003"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.150906"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202203820"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20566-6"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201802591"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja508641z"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00728-7"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202205013"},{"key":"e_1_2_7_41_1","author":"Han X.","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0494-0"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-024-01239-x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-023-01562-5"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202300662"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202311640"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202301074"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02677-x"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202516008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202516008","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202516008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:02:20Z","timestamp":1783015340000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202516008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,3]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/adma.202516008"],"URL":"https:\/\/doi.org\/10.1002\/adma.202516008","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,3]]},"assertion":[{"value":"2025-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16008"}}