{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:52:10Z","timestamp":1789735930138,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0908200"],"award-info":[{"award-number":["2020YFA0908200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFB4700100"],"award-info":[{"award-number":["2022YFB4700100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["T2225003"],"award-info":[{"award-number":["T2225003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52403175"],"award-info":[{"award-number":["52403175"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The use of micromotors\u2010based delivery systems for inflammatory bowel disease (IBD) treatment has recently gained considerable interest. The current research primarily focuses on how to design micromotors with more elaborate geometries and actuation mechanisms to improve IBD therapeutic effects. Herein, a novel type of reactive oxygen species (ROS)\u2010responsive hemispheroid adhesive micromotors (HMPs) as efficient delivery systems is developed to treat IBD. Such HMPs are fabricated through microfluidic electrospray technique, with a platinum (Pt) layer and dopamine (DOPA) coating layer covered on its top surface and baseplate, respectively. The Pt on HMPs\u2032 top surface can produce oxygen from hydrogen peroxide, thereby providing a propulsion force for them to move spontaneously upon exposure to ROS environment. Moreover, the DOPA layer on the baseplate contributed to the outstanding adhesive capacity to tissues. Therefore, by incorporating anti\u2010inflammatory dexamethasone (DXM) into HMPs, the resultant micromotor systems are imparted with superior antioxidant and anti\u2010inflammatory capacities, which also exhibits desirable therapeutic effect upon treating IBD by alleviating inflammatory response, restoring epithelial barrier functions, and mitigating IBD\u2010associated symptoms. The treatment mechanism of DXM\u2010loaded HMPs mainly involves alleviating oxidative stress, reducing proinflammatory cytokines secretion, and protecting intestinal barrier. Collectively, these results illustrate HMPs\u2010based micromotor systems are valuable for gastrointestinal disease treatment.<\/jats:p>","DOI":"10.1002\/adma.202516221","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T05:11:04Z","timestamp":1767071464000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["ROS\u2010Triggered Hemispheroid Adhesive Micromotors for Inflammatory Bowel Disease Therapy"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3718-5964","authenticated-orcid":false,"given":"Xiaoya","family":"Ding","sequence":"first","affiliation":[{"name":"MOE Innovation Center for Basic Research in Tumor Immunotherapy Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Department of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiante","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anorectal Surgery The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luoran","family":"Shang","sequence":"additional","affiliation":[{"name":"Shanghai Xuhui Central Hospital Zhongshan\u2010Xuhui Hospital and the Shanghai Key Laboratory of Medical Epigenetics the International Co\u2010laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology) Institutes of Biomedical Sciences Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-4000","authenticated-orcid":false,"given":"Yuanjin","family":"Zhao","sequence":"additional","affiliation":[{"name":"MOE Innovation Center for Basic Research in Tumor Immunotherapy Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Department of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01008-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010023\u201000854\u20104"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm3233"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0268-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010022\u201000658\u2010y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat0852"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202309972"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010019\u20100462\u20109"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj2372"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa5657"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27463-6"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.113887"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.101876"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c05143"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c02179"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-024-01224-4"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.01.028"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2023.01.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202214754"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.abo4160"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8855"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22279-w"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202212452"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201012233\u20102"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aba6137"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade6455"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400273r"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c09850"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.34133\/2022\/9850743"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202409965"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301919"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00849G"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009351\u20102"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201013336\u20106"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102249.1998.00728.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abp8798"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202301585"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202312275"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201031171\u20100"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202308728"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010022\u201000849\u20101"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.05.007"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.114101"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adl0479"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202516221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202516221","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202516221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T10:03:26Z","timestamp":1771322606000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202516221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/adma.202516221"],"URL":"https:\/\/doi.org\/10.1002\/adma.202516221","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"assertion":[{"value":"2025-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16221"}}