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In this study, a universal and simple microemulsion approach is presented using calcium dodecylbenzenesulfonate as both surfactant and calcium source, enabling the synthesis of diverse calcium\u2010based nanomaterials (e.g., calcium succinate, calcium hypophosphite, calcium metatungstate, calcium gluconate, calcium formate, and calcium citrate). To address the challenges of inadequate immune response in tumor immunotherapy, calcium succinate nanoparticle\u00a0(PCS NP) is\u00a0investigated as an example. The PCS NP exhibit enhanced immunotherapeutic potential by activating the caspase\u20101\/GSDMD\u2010mediated pyroptosis pathway via calcium overload, which in turn enhanced the immune response. Additionally, the anionic succinate component upregulates major histocompatibility complex\u2010I (MHC\u2010I) expression, enhancing antigen presentation and alleviating the immunosuppressive tumor microenvironment (TME). This microemulsion strategy provides a novel platform for calcium nanomaterial fabrication, opening new avenues for TME\u2010regulated immunotherapy enhancement, demonstrating a broad application prospect.<\/jats:p>","DOI":"10.1002\/adma.202516225","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T13:10:48Z","timestamp":1760447448000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Construction of Diverse Calcium\u2010Based Nanomaterials through a\u00a0Microemulsion Method for Pyroptosis\u2010Initiated Antitumor Immunotherapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China  Hefei 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 China"},{"name":"Key Laboratory of Superlight Materials &amp; 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