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Although currently concurrent H\n 2<\/jats:sub>\n \/ROS therapy is a promising method, the mutual reaction between H\n 2<\/jats:sub>\n and ROS dampens their efficiency. To address this issue, g\u2010C\n 3<\/jats:sub>\n N\n 4<\/jats:sub>\n \u2010based dual\u2010heterojunctions, i.e., N\u2010doped carbon nanoribbons (N\u2010CNB)\/g\u2010C\n 3<\/jats:sub>\n N\n 4<\/jats:sub>\n and core\u2013shell\u2010structured Au@Pd nanoparticles\/g\u2010C\n 3<\/jats:sub>\n N\n 4<\/jats:sub>\n , respectively, are constructed to decode alternate H\n 2<\/jats:sub>\n \/ROS therapy. Therein, N\u2010CNB\/g\u2010C\n 3<\/jats:sub>\n N\n 4<\/jats:sub>\n heterojunctions enhance near\u2010infrared (NIR) photoabsorption to unlock photocatalytic H\n 2<\/jats:sub>\n evolution, and Au@Pd\/g\u2010C\n 3<\/jats:sub>\n N\n 4<\/jats:sub>\n heterojunctions unlock the inherent and newly\u2010emerging bioenzymes\u2010like catalytic ROS birth. In this alternate H\n 2<\/jats:sub>\n \/ROS therapy, photocatalytic H\n 2<\/jats:sub>\n evolution and multienzymically\u2010catalytic ROS birth are alternately decoded under NIR \u201con\u201d and \u201coff\u201d, respectively, because the photoirradiation\u2010triggered structural shift insensitive to photothermal effects is reversible in response to NIR \u201con\u201d and \u201coff\u201d, displaying a temporal controllability. The alternate H\n 2<\/jats:sub>\n \/ROS therapy expedites the infiltrations and intratumoral proliferation of anti\u2010tumor immune cells including CTLs and Th17, hampers the infiltrations of exhausted CD8+ T cells and Tregs, and downregulates resistance\u2010associated proteins (PARP, EpCAM, and CD133). These actions cooperatively activate robust immune responses, attenuate anti\u2010tumor immunity confinements, and cancer resistance to suppress common and Sorafenib\u2010induced resistant liver cancer. This work offers distinctive insights into cancer resistance removal.\n <\/jats:p>","DOI":"10.1002\/adma.202516305","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T08:54:18Z","timestamp":1761036858000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Dual\u2010Heterojunctions with Reversibly Photoactivated Structure Shift Alternately Decode Photocatalytic H\n 2<\/sub>\n Burst and Cascade Catalytic ROS Birth to Repress Cancer"],"prefix":"10.1002","volume":"38","author":[{"given":"Duo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology Department of Ultrasound Department of Hepatobiliary Surgery Department of Gastrointestinal Surgery Guangxi Medical University Cancer Hospital Guangxi Medical University No. 71 Hedi Road Nanning Guangxi 530021 China"},{"name":"Center of Interventional Radiology & Vascular Surgery Department of Radiology Zhongda 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