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In particular, bilirubin in CSF can cause severe damage to the brain and neural tissues. Current therapeutic strategies for intracranial bilirubin clearance suffer from poor targeting, inadequate detoxification capacity, and reliance on invasive procedures. Here, we demonstrate multifunctional microrobots designed for toxin removal in specialized anatomical compartments. The proposed ultrasound\u2010trackable microbubbles@PCN\u2010333 microrobots (UMPCs) feature a hollow hydrogel microbubble core for enhanced ultrasound imaging contrast, an outer metal\u2013organic framework (MOF) layer for proactive and high\u2010capacity toxin adsorption, and embedded ferroferric oxide (Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    ) nanoparticles to enablec. Magnetic actuation enhances the UMPC's bilirubin capture efficiency through improved mass transfer. By integrating an ultrafast ultrasound imaging system with magnetic actuation, we achieve real\u2010time tracking and precise control of UMPCs within the CSF. This strategy offers a minimally invasive and actively guided approach for efficient intracranial bilirubin clearance, opening new avenues for targeted toxin\u2010removal in anatomically confined environments.\n                  <\/jats:p>","DOI":"10.1002\/adma.202516357","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T08:00:52Z","timestamp":1766995252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["MOF\u2010Functionalized Ultrasound\u2010Trackable Magnetic Microrobots for Intracranial Toxin Removal"],"prefix":"10.1002","volume":"38","author":[{"given":"Yu","family":"Mei","sequence":"first","affiliation":[{"name":"International Institute for Intelligent Nanorobots and Nanosystems College of Intelligent Robotics and Advanced Manufacturing State Key Laboratory of Surface Physics, and State Key Laboratory of Photovoltaic Science and Technology Fudan University  Shanghai P. 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