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In this study, a bioinspired force\u2010inducible multichannel nerve guide conduit (FI\u2010MNGC) is developed, constructed from silk fibrin\u2010based hydrogel. By mimicking the gradient capillary architectures in vascular plants, the FI\u2010MNGC utilizes a multichannel design with gradient apertures that can self\u2010generate enhanced capillary forces, which not only promote directed axon growth but also guide the directed delivery of Schwann cells (SCs) toward the distal ends of the injured nerve, without the need for any external stimuli. Implemented in a rat model with a 16\u00a0mm and a rabbit model with a 30\u00a0mm long\u2010gap sciatic nerve defect, the FI\u2010MNGC significantly accelerates the recovery process, paralleling the efficacy of autografts in nerve regeneration, functional recovery, and repair speed. This innovative approach offers a promising alternative to autografts, enhancing the potential for clinical implementation in long\u2010gap PNI therapies.<\/jats:p>","DOI":"10.1002\/adma.202516449","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T05:30:17Z","timestamp":1764394217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A Bioinspired Force\u2010Inducible Hydrogel Conduit for Peripheral Nerve Regeneration"],"prefix":"10.1002","volume":"38","author":[{"given":"Dongwei","family":"Lan","sequence":"first","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University  Xi'an 710049 P. R. China"},{"name":"Bioinspired Engineering and Biomechanics Center (BEBC) Xi'an Jiaotong University  Xi'an 710049 P. R. 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