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However, the low frequency of pro\u2010inflammatory immune cells and the immunosuppressive tumor network pose substantial challenges to achieving potent immunogenic cell death. This study designs a multiphase phase\u2010transition nano\u2010disruptor (V\u2010MoS\n                    <jats:sub>2<\/jats:sub>\n                    &amp;CaF\n                    <jats:sub>2<\/jats:sub>\n                    @HA), inspired by ionic interference and metabolic inhibition, to target multiple immunosuppressive mechanisms in tumors. Vanadium\u2010doping engineering induces the coexistence of the 2H (semiconducting) and 1T (metallic) phases, maximizing the ability of piezocatalysts to enhance charge\u2010carrier mobility. Critically, V\u2010MoS\n                    <jats:sub>2<\/jats:sub>\n                    with its ultrathin, asymmetrical layered architecture, reinforces the piezoelectric response by promoting band bending and charge\u2010carrier separation, thereby establishing favorable conditions for efficient electron\u2013hole separation and reactive oxygen species generation. Concurrently, calcium\u2010ion self\u2010amplifying leakage and hydrogen sulfide liberation collectively create an \u201cion\u2010interference\u2013metabolic\u2010hijacking\u201d effect that induces oxidative stress, amplifies innate immune cGAS\u2013STING pathway activation, and triggers a pyroptosis\u2013apoptosis cross\u2010death effect and immune activation. Thus, the study offers a straightforward strategy to achieve antitumor immunity through STING pathway activation and provides a new avenue to robustly activate immunogenic cell death for tumor treatment.\n                  <\/jats:p>","DOI":"10.1002\/adma.202516688","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T13:01:40Z","timestamp":1765285300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Triple\u2010Kill Nano\u2010Disruptor Integrating Ion Interference, Metabolic Inhibition, and Immune Activation for Augmented Apoptosis and Pyroptosis\u2010Mediated Immunotherapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Shiyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin 150001 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