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While low\u2010level vagus nerve stimulation (LL\u2010VNS) offers therapeutic benefits, its clinical application is limited by the need for surgical implants. Here, we present a noninvasive, orally delivered magnetoelectric neuroimmunomodulation platform that targets the gut\u2013brain\u2013spleen\u2013heart axis to deliver LL\u2010VNS for AF therapy. The platform comprises ingestible microparticles (MPs) embedding magnetostrictive Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    @BaTiO\n                    <jats:sub>3<\/jats:sub>\n                    nanogenerators (FO@BTO NGs) within a conductive matrix of poly(3,4\u2010ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), which facilitates electrical signal transmission, and dopamine\u2013alginate, which promotes gastric adhesion via catechol\u2010mediated interactions. After oral gavage in a rat AF model, MPs adhere to the stomach lining and, upon alternating magnetic activation, FO@BTO NGs generate pulsed electrical currents that stimulate vagal afferent fibers. This activates brainstem autonomic circuits, enhancing parasympathetic tone and suppressing sympathetic activity. Concurrently, it engages the splenic neuroimmune circuit via the cholinergic anti\u2010inflammatory pathway, thereby reducing systemic inflammation. This dual neuroimmune modulation significantly shortens AF duration and mitigates cardiac inflammation and electrical remodeling. These findings establish a clinically translatable, implant\u2010free strategy for delivering LL\u2010VNS through coordinated neural and immune pathways, offering a safe and accessible alternative to implantable systems for AF management.\n                  <\/jats:p>","DOI":"10.1002\/adma.202516956","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T09:22:28Z","timestamp":1770369748000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oral Magnetoelectric Neuroimmunomodulation via the Gut\u2013Brain\u2013Spleen\u2013Heart Axis for Noninvasive Atrial Fibrillation Therapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Cam\u2010Hoa","family":"Mac","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering National Tsing Hua University  Hsinchu 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