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Specific clearance of lipopolysaccharides (LPSs), key pathological drivers in sepsis, from the bloodstream is critical for effective therapy. However, selective capture of LPS is challenging due to their structural heterogeneity, extremely low concentrations (ng\u00b7mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), and complexity of blood components. Here, a novel dual\u2010affinity strategy is presented for designing high\u2010specificity LPS adsorbents. Leveraging phage display, a high\u2010affinity peptide ligand (P\u2010HK) targeting the LPS family is identified by screening against their conserved Kdo\n                    <jats:sub>2<\/jats:sub>\n                    \u2010Lipid A structure. Concurrently, delicate molecularly imprinted polymers (PS@PA+) with geometrically matched cavities are synthesized via emulsion interfacial polymerization, exploiting the oriented assembly of amphiphilic LPS templates at oil\u2010water interfaces. Conjugation of the imprinted polymers with the peptide ligand produced PS@PA\u2010P\n                    <jats:sub>HK<\/jats:sub>\n                    +, which exhibits highly specific LPS binding and demonstrates exceptional performance, including remarkable\n                    <jats:italic>E. coli<\/jats:italic>\n                    LPS clearance efficiency (99.2% in buffer; 95.4% in blood), high adsorption capacity (543 EU\u00b7mg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), broad\u2010spectrum clearance of diverse bacterial LPSs, robust anti\u2010fouling properties, and satisfactory biocompatibility. Furthermore, PS@PA\u2010P\n                    <jats:sub>HK<\/jats:sub>\n                    +\u2010based hemoperfusion in a septic rabbit model confirmed significant therapeutic efficacy, remarkably reducing circulating LPS levels and mitigating organ damage. This material design overcomes the challenge of specific LPS clearance, offering substantial promise for transformative sepsis therapy.\n                  <\/jats:p>","DOI":"10.1002\/adma.202517135","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T07:03:26Z","timestamp":1763708606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Unique Dual\u2010Affinity Strategy for Specific Lipopolysaccharide Clearance in Sepsis Therapy: Peptide\u2010Conjugated Molecularly Imprinted Polymers via Emulsion Interfacial Polymerization"],"prefix":"10.1002","volume":"38","author":[{"given":"Haijie","family":"Wei","sequence":"first","affiliation":[{"name":"Key Laboratory of Phytochemistry and Natural Medicines, Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian 116023 P. R. 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