{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:58:56Z","timestamp":1790798336538,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>To address the balance between mechanical strength and flexibility in absorbable tissue ligation clips, a novel copolymer poly(L\u2010lactide\u2010r\u2010\u03b5\u2010caprolactone)\u2010b\u2010poly(L\u2010lactide) (PLCL\u2010b\u2010PLLA) with random\u2010block molecular architecture is developed by integrating the flexibility of PLCL random copolymer and the high strength of PLLA homopolymer. Three random\u2010block copolymers with different LLA\/CL ratios are designed and synthesized. Among them, the copolymer with an LLA\/CL ratio of 75:25 (PLC75\u2010RB) exhibits the most balanced overall performance. The PLC75\u2010RB copolymer is injected into Hem\u2010o\u2010lok\u2013shaped clips (CLIP75\u2010RB), and the CLIP75\u2010RB possesses sufficient closure force and favorable rebound ability, meeting the requirements for tissue ligation. The degradation evaluation indicates that the CLIP75\u2010RB maintains effective closure force for up to 4 weeks and then begins to degrade gradually. Further validation in a rabbit unilateral nephrectomy model confirms that CLIP75\u2010RB effectively performs ligation function and subsequently undergoes controlled degradation. The histological analysis demonstrates the good biocompatibility of the clips. The random\u2010block PLCL\u2010b\u2010PLLA copolymers expand the range of biodegradable polymers, and the PLC75\u2010RB exhibits well\u2010matched mechanical performance and degradation behavior, highlighting the potential for the next generation of absorbable tissue ligation clips.<\/jats:p>","DOI":"10.1002\/adma.202517245","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T15:08:07Z","timestamp":1766588887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tailored Biodegradable Copolymers With Random\u2010Block Architecture for High\u2010Performance Absorbable Tissue Ligation Clips"],"prefix":"10.1002","volume":"38","author":[{"given":"Quan","family":"Zhao","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Biomaterials, College of Biomedical Engineering Sichuan University  Chengdu 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