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Efficient production of its valuable degradation products requires highly selective catalysts. This study introduces a spin\u2010state\u2010modulated nanozyme system for precise lignin depolymerization into targeted biobased chemicals. Precise copper spin state control in two\u2010dimensional (2D) copper\u2010based metal organic framework (MOF) nanozymes, achieved via redox treatment and ligand exchange modulation, replicates natural laccase multicopper center spin synergy. Integrated experiments and theory reveal a volcano\u2010shaped spin state\u2010activity correlation, enabling synthesis of optimized nanozyme Cu(OH)\n                    <jats:sub>2<\/jats:sub>\n                    BDC\u2010LA\u2010OAc (COHBLO). This material demonstrates exceptional laccase\u2010mimicking activity, with a peak reaction rate 70 times higher than natural laccase and a 5.14\u2010fold specific activity increase. Through laccase\u2010like catalysis, it selectively cleaves lignin \u03b2\u2010O\u20104 linkages, directionally yielding fragments rich in phenolic hydroxyl groups. Their efficient reaction with epoxy groups produces a nanolignin\u2010based epoxy adhesive. Featuring a three\u2010dimensional cross\u2010linked network, this adhesive delivers superior bonding under varied conditions. Its shear strength significantly surpasses commercial phenolic resins while eliminating conventional adhesive formaldehyde emissions. This study advances 2D MOF nanozyme design and establishes an integrated pathway from controlled lignin depolymerization to high\u2010performance adhesive production, providing key theoretical and practical foundations for biomass valorization and sustainable adhesive development.\n                  <\/jats:p>","DOI":"10.1002\/adma.202517928","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T08:39:23Z","timestamp":1764146363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A Spin\u2010Engineered Nanozyme Overcomes the Activity\u2010Selectivity Trade\u2010Off for Sustainable Adhesive Production From Lignin Biomass Conversion"],"prefix":"10.1002","volume":"38","author":[{"given":"Yixin","family":"Yu","sequence":"first","affiliation":[{"name":"CAS Engineering Laboratory for Nanozyme State Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences  Beijing 100101 P. 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