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Herein, we report a new strategy incorporating Ni into ultrathin PtPdRh nanosheets to engineer lattice strain for enhancing substrate affinity and boosting enzyme\u2010mimicking catalytic activity. The PtPdRhNi nanozyme achieves a catalytic efficiency (K\n                    <jats:sub>cat<\/jats:sub>\n                    \/K\n                    <jats:sub>m<\/jats:sub>\n                    = 2.05 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    \u00a0\n                    <jats:sc>m<\/jats:sc>\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00a0s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), 56.5\u2010fold higher than PtPdRh and maintains over 90% activity after 15 months. Theoretical calculations reveal Ni incorporation upshifts the\n                    <jats:italic>d<\/jats:italic>\n                    \u2010band center from \u22121.80 to \u22121.27\u00a0eV and strengthens Pt\u2500O bonding, thus accelerating the activation of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    into \u00b7OH. We further demonstrate that PtPdRhNi co\u2010treated with H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    achieves 100% eradication of methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    and\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    , as well as over 99.97% killing of\n                    <jats:italic>Streptococcus mutans<\/jats:italic>\n                    and\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    . Across rat periodontitis,\n                    <jats:italic>MRSA<\/jats:italic>\n                    \u2010infected skin wounds and deep abscess models, this catalytic platform enables rapid bacterial clearance, resolves inflammation and regenerates collagen\u2010rich tissue. Transcriptomic analysis of\n                    <jats:italic>MRSA<\/jats:italic>\n                    exposed to PtPdRhNi with H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    identifies 1048 differentially expressed genes, revealing respiratory chain and tricarboxylic acid cycle shutdown, weakened antioxidant defenses, leading to energy exhaustion, oxidative damage and transcriptomic reprogramming.\n                  <\/jats:p>","DOI":"10.1002\/adma.202518526","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:44:03Z","timestamp":1767339843000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Precise Strain Tuning of PtPdRhNi Nanozyme Boosts Multi\u2010Pathogen and Multi\u2010Model Antibacterial Therapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Ruijin","family":"Zeng","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering Peking University  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqiu","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of General Dentistry II Peking University School and Hospital of Stomatology &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing P. R. China"},{"name":"The VIP Department Liaoning Provincial Key Laboratory of Oral Diseases School and Hospital of Stomatology, China Medical University  Shenyang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Peking University  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghao","family":"Qiu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Xiamen University  Xiamen P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of General Dentistry II Peking University School and Hospital of Stomatology &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Peking University  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglong","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Peking University  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Peking University  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yan","sequence":"additional","affiliation":[{"name":"The VIP Department Liaoning Provincial Key Laboratory of Oral Diseases School and Hospital of Stomatology, China Medical University  Shenyang P. R. 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