{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T11:30:45Z","timestamp":1788003045163,"version":"build-2784847793"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52325305"],"award-info":[{"award-number":["52325305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52403199"],"award-info":[{"award-number":["52403199"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270059"],"award-info":[{"award-number":["82270059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20240361"],"award-info":[{"award-number":["BK20240361"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Maintaining nerve integrity and rescuing\/regenerating injured neurons are pivotal for spinal cord injury (SCI) repair. Herein, an immuno\u2010neuroprotectant (INPT) is developed to mitigate secondary SCI and promote neuroregeneration via sequestration of neutrophil extracellular traps (NETs) and targeted delivery of brain\u2010derived neurotrophic factor (BDNF). To construct the INPT, positively charged BDNF is engineered into negatively charged A\u2010BDNF nanoparticles (A\u2010BDNF NPs) via reversible modification with adenosine triphosphate, and A\u2010BDNF NPs are further coated with polySia\u2010overexpressing microglia membrane (PBM). In SCI mice, intravenously injected INPT effectively accumulates in the injured spinal cord and then binds to NETs through the over\u2010expressed polySia on PBM. This binding triggers PBM shedding from the NPs, and thereby, phosphatidylserine localized at the cytoplasmic leaflet of PBM is exposed and displayed on the NETs surface. Consequently, the PBM\u2010bound NETs are cleared by phagocytes via efferocytosis, which provokes neuroprotective immune responses. Meanwhile, the mildly acidic environment triggers traceless restoration of A\u2010BDNF NPs to the native BDNF to foster neuroregeneration. Thus, PBM\u2010mediated NETs sequestration cooperates with BDNF\u2010mediated neuroregeneration to restore neurological recovery. This study provides an enlightened approach for remedying NET\u2010associated pathophysiological aberrations and also renders a facile yet effective platform for biomacromolecule delivery to the central nervous system.<\/jats:p>","DOI":"10.1002\/adma.202518580","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T07:33:02Z","timestamp":1768375982000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immuno\u2010Neuroprotectants Facilitate Neurological Recovery via Sequestration of Neutrophil Extracellular Traps (NETs) and Promotion of Neuroregeneration"],"prefix":"10.1002","volume":"38","author":[{"given":"Lucheng","family":"Xie","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory For Carbon\u2010Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dudu","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory For Carbon\u2010Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory For Carbon\u2010Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehan","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory For Carbon\u2010Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory For Carbon\u2010Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Ye","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory For Carbon\u2010Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory For Carbon\u2010Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Second Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4573-0555","authenticated-orcid":false,"given":"Lichen","family":"Yin","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory For Carbon\u2010Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(23)00366\u20106"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(23)00287\u20109"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/procel\/pwad003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202403900"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202407958"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102229"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c00360"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001477\u20106"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4294"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.105"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3235524"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202304648"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201028172\u20104"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001933\u2010x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa8064"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010022\u201000787\u20100"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9092130"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3399"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101218"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010018\u20100467\u20106"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c06991"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304896"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(24)00482\u20104"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3366"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202413957"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169\u2010409X(98)00086\u20106"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.677"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201703982"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201001010\u20101"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201013854\u20103"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202416572"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17623"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c12036"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201900727"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3BM00340J"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.07.010"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.01.015"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21721"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202108817"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmm2.12112"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.07.024"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202210691"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.06.015"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202410529"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl6432"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113609"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201020231\u2010y"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061679"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22815"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010020\u201003601\u2010z"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300180"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c10509"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202307664"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3NR06371B"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.07.024"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.344.6188.1128\u2010a"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202002988"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.626110.<\/bib"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202518580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202518580","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202518580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:46:26Z","timestamp":1783115186000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202518580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,13]]},"references-count":59,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/adma.202518580"],"URL":"https:\/\/doi.org\/10.1002\/adma.202518580","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,13]]},"assertion":[{"value":"2025-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e18580"}}