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However, bacterial metal transport proteins (MTP) and antioxidant systems can reduce iron accumulation and lipid peroxidation, limiting the efficacy of ferroptosis\u2010based therapies and promoting resistance. Single\u2010atom and chiral nanozymes, with their high atomic utilization and catalytic specificity, may provide an effective approach to overcoming bacterial defense mechanisms, which has been not exploited. In this study, we report D\u2010chiral single\u2010atom iron\u2013carbon dot nanozymes (DFe\u2010NSC) for effective bacterial infection treatment. Compared to L\u2010chiral form (LFe\u2010NSC), DFe\u2010NSC exhibits significantly higher peroxidase (POD)\u2010like and glutathione peroxidase (GPx)\u2010like activities. The enhanced catalytic activity promotes reactive oxygen species (ROS) generation and glutathione depletion, disrupting bacterial redox homeostasis. More intriguingly, DFe\u2010NSC more effectively modulates the expression and iron\u2010regulatory function of MTP (including Fur and FtnA) than LFe\u2010NSC. This will induce substantial accumulation of Fe\n                    <jats:sup>2<\/jats:sup>\n                    \u207a intracellularly and thereafter lipid peroxidation, thereby facilitating the bactericidal effects of ferroptosis\u2010like cell death. Resultantly, DFe\u2010NSC exhibit markedly enhanced antibacterial and antibiofilm activities in diabetic infected wound and osteomyelitis models. This study introduces a chiral catalysis\u2013MTP regulation strategy to induce bacterial ferroptosis\u2010like death, providing a promising alternative for drug\u2010resistant infection treatment.\n                  <\/jats:p>","DOI":"10.1002\/adma.202518810","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T12:31:11Z","timestamp":1767097871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Chiral Single\u2010Atom Nanozymes\u2010Enabled ROS Catalysis and Metal Transport Regulation Cooperatively Induce Ferroptosis to Treat Bacterial Infections"],"prefix":"10.1002","volume":"38","author":[{"given":"Zekun","family":"Wang","sequence":"first","affiliation":[{"name":"Anhui Engineering Technology Research Center of Biochemical Pharmaceutical School of Pharmacy Bengbu Medical University  Bengbu 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