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However, its efficacy is hampered by limited CNS targeting efficiency and rapid clearance in the nasal microenvironment. Here, a Ca\n                    <jats:sup>2+<\/jats:sup>\n                    responsive alginate hydrogel drug delivery system (namely SA@T\n                    <jats:sup>SCC<\/jats:sup>\n                    ) encapsulating a STING inhibitor within a neuronal targeting aptamer\u2010modified DNA nanocage for intranasal administration is developed. SA@T\n                    <jats:sup>SCC<\/jats:sup>\n                    demonstrates enhanced nasal retention, sustained release, and efficient transport of cargo into the CNS, leading to robust accumulation in the brain and spinal cord of experimental autoimmune encephalomyelitis (EAE) mice, eventually promoting remyelination, suppressing neuroinflammation, and restoring motor function. Mechanistically, SA@T\n                    <jats:sup>SCC<\/jats:sup>\n                    , acting as a molecular \u201cgardener\u201d in the diseased CNS \u201cecosystem,\u201d could directly repair \u201cstressed plants\u201d neurons by inhibiting STING\u2010autophagy\u2010ferroptosis, restore neuronal health instead of broadly spraying \u201cpesticides\u201d immunosuppressants, calm \u201cdisrupted pollinators\u201d microglia, and reverse neuroinflammation. Despite the exploration of STING inhibition for EAE treatment, the concept of nose\u2010to\u2010brain drug delivery and neuron targeting intranasal platform enabling precise modulation of the CNS microenvironment could be further extended for other chronic neurodegenerative diseases.\n                  <\/jats:p>","DOI":"10.1002\/adma.202518814","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:26:16Z","timestamp":1768569976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Molecular Gardening for Neuroinflammation via Nose\u2010to\u2010Brain Delivery: A Ca\n                    <sup>2+<\/sup>\n                    Responsive DNA Nanocage\u2010Hydrogel System With Neuron Targeting and STING Inhibiting"],"prefix":"10.1002","volume":"38","author":[{"given":"Xinran","family":"Shen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu Sichuan 610041 P. 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