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However, the lack of sustained anti\u2010tumor efficacy and wear caused by configuration or deformation discrepancies has led to the recurrence of stenosis, posing a significant challenge in clinical treatment. Here, we reported an intestine\u2010specific, application\u2010driven 4D\u2010printed sandwich\u2010structured metamaterial intestinal stent platform, achieving the triple goals of sustained anti\u2010tumor effects, customized configuration and performance, and rapid relief of intestinal obstruction. Specifically, the platform comprised an outer Janus layer designed for synergistic photothermal\u2010and\u2010drug anti\u2010tumor effects, an intermediate layer of biomimetic gradient metamaterials for structural support and coordinated deformation, and a hydrophobic inner layer to mitigate the risk of restenosis. Overall, this study presented a multifunctional intestinal stent built upon a scalable design paradigm, offering an innovative and clinically translatable therapeutic strategy for personalized colorectal cancer management.<\/jats:p>","DOI":"10.1002\/adma.202518990","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:36:17Z","timestamp":1778056577000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["4D\u2010Printed Sandwich\u2010Structured Metamaterial Intestinal Stents for Palliative Tumor Therapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Cheng","family":"Lin","sequence":"first","affiliation":[{"name":"Centre For Composite Materials and Structures Harbin Institute of Technology  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Centre For Composite Materials and 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