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Guided by molecular dynamics simulations of MV\u2010polymer interactions, we engineered imidazolium\u2010based poly(ionic liquid) (PIL) electrospun nanofibers for targeted MV interception. Among multiple formulations, PIL\u2010C4 demonstrated optimal performance, combining potent antibacterial activity, robust adsorption of methicillin\u2010resistant\n                    <jats:italic>S. aureus<\/jats:italic>\n                    (MRSA) MVs and their virulence factors, minimal cytotoxicity, and inhibition of resistance transmission. In vivo, PIL\u2010C4 attenuated MV\u2010induced neutrophil extracellular trap (NET) formation (NETosis) and vascular leakage, thereby reducing purulent\u2010exudative wound injury and preventing systemic organ damage, including fatal lung injury. Notably, DNase\u2010mediated NET degradation alone failed to rescue MV pathology, underscoring the necessity of direct MV clearance. This study uncovers previously unrecognized NETosis\u2010driven phenotypes of\n                    <jats:italic>S. aureus<\/jats:italic>\n                    MVs\u2014local purulent\u2010exudative wound injury and systemic lethal lung damage\u2014and establishes a polymer\u2010based clearance strategy with translational potential for infection control.\n                  <\/jats:p>","DOI":"10.1002\/adma.202519131","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:24:22Z","timestamp":1768292662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Poly(Ionic Liquid) Nanofibers Suppress\n                    <i>S. aureus<\/i>\n                    Membrane Vesicle\u2010Induced NETosis to Mitigate Wound and Lung 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