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Exploiting the innate capacity of macrophages to recognize and neutralize pathological stimuli, this study develops novel engineered macrophage\u2010based materials: phytate\/Zn\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    \u2010loaded gelated macrophages (PZ\u2010GMs). These materials are fabricated at room temperature by polymerizing polycationic hydrogels and loading phytate\/Zn\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    into live macrophages, innovatively integrating the natural immune neutralization function of intact macrophage membranes with the bioactivity of intracellular hydrogels. PZ\u2010GMs are found to eradicate &gt;99.99% of pathogens, remove &gt;90% of bacterial toxins, and eliminate &gt;80% of related inflammatory factors, while simultaneously promoting bone repair through in situ mineralization and osteoinduction. They can be further incorporated into a hydrogel designed for acid\u2010triggered release, ensuring targeted delivery to inflamed sites. In a murine periodontitis model, PZ\u2010GMs facilitate periodontal regeneration via a dual mechanism: transforming the pathological microenvironment induced by bacteria and toxins and fostering the remodeling of an osteogenic microenvironment. Furthermore, oral microbiome homeostasis is restored. Collectively, PZ\u2010GMs represent a promising all\u2010in\u2010one neutralization\u2013eradication\u2013osteopromotion material for highly efficient periodontitis therapy.\n                  <\/jats:p>","DOI":"10.1002\/adma.202519288","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:47:28Z","timestamp":1782233248000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Macrophages Intracellularly Gelated With Bioactive Hydrogels for Synergistic Neutralization, Eradication, and Osteopromotion in Periodontitis Treatment"],"prefix":"10.1002","volume":"38","author":[{"given":"Mingyi","family":"Liu","sequence":"first","affiliation":[{"name":"National Clinical Research Center For Oral Diseases State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi P. R. 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