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Its success critically depends on repair strategies with precise spatiotemporal control. External field\u2010responsive biomaterials (EFRBs), which respond to optical, magnetic, electrical, ultrasonic, and thermal stimuli, have become a research focus in regenerative medicine due to their on\u2010demand activation, unique (bio)physicochemical properties, and ability to modulate immune\u2010related pathways. This review first outlines the dynamic biological requirements of tissue repair, including the immune microenvironment's role, and the core advantages of EFRBs. It then details the structural features and external field response mechanisms of various EFRBs\u2014such as nanoparticles, scaffolds, hydrogels, and microneedles\u2014and their regulatory effects on immune\u2010related repair processes. Finally, it systematically summarizes recent advances in immunoengineering EFRBs for enhancing tissue repair and regeneration. This review thus aims to provide valuable insights for optimizing EFRB\u2010based therapies and to inspire further breakthroughs in this evolving field.<\/jats:p>","DOI":"10.1002\/adma.202519723","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:22:37Z","timestamp":1780471357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immunoengineering External Field Responsive Biomaterials for Tissue Repair and Regeneration"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3025-1376","authenticated-orcid":false,"given":"Wanli","family":"Song","sequence":"first","affiliation":[{"name":"Department of Dental Materials &amp; Dental Medical Devices Testing Center Peking University School and Hospital of Stomatology  Beijing P. R. China"},{"name":"Department of Geriatric Dentistry Peking University School and Hospital of Stomatology  Beijing P. R. 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