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Here we introduce SP\u201013786 (SP), a precise small\u2010molecule inhibitor of fibroblast activation protein (FAP), as a universal and effective excipient enabling facile co\u2010precipitation into stable nanoparticles (SCAN) with diverse hydrophobic drugs. Screening of 861 compounds revealed a broadly enhanced colloidal stability and drug loading by SP. Corresponding simulations and explainable machine learning (XML) showed SCAN assembly hinges on balanced aromaticity, rigidity, and nitrogen\u2010mediated interaction, offering interpretable framework for co\u2010assembly nanomedicine. Biological assessment demonstrate that SCAN enhances drug delivery and therapeutic efficacy in FAP\u2010positive cells, therefore attentuate the fibrosis\u2010induced drug penetration barriers, increasing drug accumulation within the fibrotic tissue. The improved bioavailability correlate with superior therapeutic outcomes in multiple disease models with progressive fibrosis. 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