{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:02:24Z","timestamp":1790391744599,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"54","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22374152"],"award-info":[{"award-number":["22374152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22477139"],"award-info":[{"award-number":["22477139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22174145"],"award-info":[{"award-number":["22174145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22122411"],"award-info":[{"award-number":["22122411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Customizing sense\u2010and\u2010respond programs that link natural actuations with user\u2010defined cues has emerged as a promising strategy for modulating life processes. Herein, a metal\u2013organic framework (MOF)\u2010based synthetic receptor system is presented for realizing customized biological functions using write\u2010in signaling gates. This is achieved by integrating glucose oxidase into a series of engineered Zr\u2010MOF nanosheets. Notably, ultrathin MOF architectures act as synthetic allosteric regulators by reshaping the interaction network at the enzyme\u2013dimer interface, thus compromising electron\u2010transfer efficiency during catalysis. Leveraging this mechanism, activity modulation is achieved by converting an endogenous yet functionally irrelevant protein, serum albumin, into an activating cue for enzymatic catalysis. This MOF\u2013enzyme system with an albumin\/glucose dual\u2010gated output behavior exhibits effective antibacterial activity through kinetically controlled oxidative stress. The therapeutic efficacy is demonstrated in a diabetic wound\u2010healing model. These findings establish MOFs as versatile modules for constructing synthetic receptor systems to advance their use in precision biomedicine.<\/jats:p>","DOI":"10.1002\/adma.202519828","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T05:41:47Z","timestamp":1770270107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ultrathin Metal\u2013Organic Framework as an Allosteric Regulator for Albumin\u2010Responsive Therapy of Diabetic Infections"],"prefix":"10.1002","volume":"38","author":[{"given":"Yongming","family":"Li","sequence":"first","affiliation":[{"name":"Beijing National Laboratory For Molecular Sciences CAS Key Laboratory of Analytical Chemistry For Living Biosystems CAS Research\/Education Center For Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences  Beijing China"},{"name":"School of Chemical Science University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rao","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"Pharmacy Department of Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixia","family":"Feng","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory For Molecular Sciences CAS Key Laboratory of Analytical Chemistry For Living Biosystems CAS Research\/Education Center For Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences  Beijing China"},{"name":"School of Chemical Science University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Lei","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory For Molecular Sciences CAS Key Laboratory of Analytical Chemistry For Living Biosystems CAS Research\/Education Center For Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences  Beijing China"},{"name":"School of Chemical Science University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Gao","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory For Molecular Sciences CAS Key Laboratory of Analytical Chemistry For Living Biosystems CAS Research\/Education Center For Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences  Beijing China"},{"name":"School of Chemical Science University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7191-9354","authenticated-orcid":false,"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory For Molecular Sciences CAS Key Laboratory of Analytical Chemistry For Living Biosystems CAS Research\/Education Center For Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences  Beijing China"},{"name":"School of Chemical Science University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4760-6865","authenticated-orcid":false,"given":"Hai\u2010Yu","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2930-6471","authenticated-orcid":false,"given":"Yanyan","family":"Huang","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory For Molecular Sciences CAS Key Laboratory of Analytical Chemistry For Living Biosystems CAS Research\/Education Center For Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences  Beijing China"},{"name":"School of Chemical Science University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201008282\u20103"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010021\u201000926\u2010z"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.3c00225"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201008366\u20100"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat6982"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201053960\u20105"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1994"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c16008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010018\u20100155\u2010z"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr300014x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS90059F"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230444"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202302997"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202508105"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202400829"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00386H"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202502163"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202407194"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201052567\u20100"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c01989"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202423741"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202407831"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010025\u201001827\u20107"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01029"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202302436"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00879"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2018.03.001"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax5785"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202301457"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b10302"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b03450"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001680\u20105"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202400129"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202212527"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2020.10.006"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2689"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101528\u20101"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic5012764"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201802059"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abk1391"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c11764"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444999003431"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119793304"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.9b02413"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2025.128149"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3TB01097J"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202405644"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2025.03.006"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.017"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adn2804"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524\u2010475X.1996.40211.x"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201002879\u20109"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202408360"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj0153"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202519828","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202519828","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202519828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:37:41Z","timestamp":1790390261000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202519828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":54,"journal-issue":{"issue":"54","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/adma.202519828"],"URL":"https:\/\/doi.org\/10.1002\/adma.202519828","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,4]]},"assertion":[{"value":"2025-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e19828"}}