{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:31:57Z","timestamp":1791909117576,"version":"4.3.4"},"reference-count":79,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2510700"],"award-info":[{"award-number":["2024YFC2510700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFE0201200"],"award-info":[{"award-number":["2024YFE0201200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1104400"],"award-info":[{"award-number":["2022YFA1104400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52373148"],"award-info":[{"award-number":["52373148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52173133"],"award-info":[{"award-number":["52173133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52525311"],"award-info":[{"award-number":["52525311"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82561160101"],"award-info":[{"award-number":["82561160101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2022YFA1104400"],"award-info":[{"award-number":["2022YFA1104400"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010903","name":"Key Programme","doi-asserted-by":"publisher","award":["U24A20712"],"award-info":[{"award-number":["U24A20712"]}],"id":[{"id":"10.13039\/501100010903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Periodontitis, characterized by tenacious polymicrobial biofilms and persistent oxidative stress, presents a formidable therapeutic challenge in clinical practice. Current treatment modalities often fall short in achieving simultaneous biofilm eradication and inflammatory resolution. Here, we present the de novo design of high\u2010entropy alloy (HEA, PtPdRuRhIr)\u2010based artificial enzymes with modulated d\u2010band center and pH\u2010controllable biocatalysis of reactive oxygen species (ROS) for stage\u2010specific treatment of inflammatory and infectious periodontitis. Our studies demonstrate that the unique structure of PtPdRuRhIr\u2010based HEA stabilizes the d\u2010band center, enhances the electron density of Ru atoms, and optimizes the binding strength of oxygen species, thus enabling exceptional ROS biocatalysis and pH\u2010controllable switching between antioxidase\u2010like functions at physiological pH conditions and peroxidase\u2010like activity under acidic infectious environments. Therefore, the PtPdRuRhIr\u2010based HEA simultaneously exhibits superior regenerative functions by mitigating oxidative damage and bioadaptive antibacterial properties by generating bactericidal ROS. Comprehensive in vitro and in vivo evaluations demonstrate suppression of inflammatory cytokines, functional regeneration of alveolar bone, and also microenvironment\u2010adaptive disruption of biofilm. By integrating pH\u2010dependent anti\u2010inflammatory and antimicrobial activities with immunomodulatory capacity in a single nanoplatform, this smart biocatalyst represents a promising therapeutic strategy for periodontitis and other biofilm\u2010associated inflammatory disorders, effectively bridging the gap between microbial clearance and tissue restoration.<\/jats:p>","DOI":"10.1002\/adma.202519865","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T06:35:38Z","timestamp":1766817338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["High\u2010Entropy Alloy\u2010Based Artificial Enzymes With Modulated D\u2010Band Center and pH\u2010Controllable ROS Biocatalysis for Stage\u2010Specific Treatment of Inflammatory and Infectious Oral Diseases"],"prefix":"10.1002","volume":"38","author":[{"given":"Huili","family":"Du","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center For Stomatology National Clinical Research Center For Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"},{"name":"Department of Orthodontics West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihuan","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center For Stomatology National Clinical Research Center For Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Oral Sciences Faculty of Dentistry University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Adeli","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Free University of Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering The Macau University of Science and Technology  Taipa Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center For Stomatology National Clinical Research Center For Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7650-8204","authenticated-orcid":false,"given":"Xianglong","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center For Stomatology National Clinical Research Center For Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"},{"name":"Department of Orthodontics West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1296-7772","authenticated-orcid":false,"given":"Tian","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center For Stomatology National Clinical Research Center For Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"},{"name":"Department of Orthodontics West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6872-2240","authenticated-orcid":false,"given":"Chong","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center For Stomatology National Clinical Research Center For Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"},{"name":"College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.38"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13506"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21-0625"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202310636"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201053290\u20106"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1318"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.1998.tb02419.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2337"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2329\/perio.31.241"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003\u20109969(91)90091\u20108"},{"key":"e_1_2_9_13_1","first-page":"56","article-title":"Plaque, Plaque Model Systems and pH","volume":"94","author":"Sissons C.","year":"1998","journal-title":"New Zealand Dental Journal"},{"key":"e_1_2_9_14_1","first-page":"61","article-title":"The Relevance of pH to Gingivitis and Periodontitis","volume":"3","author":"Galgut P. N.","year":"2001","journal-title":"Journal of the International Academy of Periodontology"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202302908"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201043415\u20108"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201040830\u20109"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274\u2010024\u20106828\u20106"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202404091"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c13562"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c03256"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202311459"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c04242"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c03510"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.102113"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c13965"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202214454"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM01036D"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202210850"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2025.2522109"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304967"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201062063\u20108"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202507226"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.12.041"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c04655"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1775"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.4c00646"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.07.003"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.4c01869"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.06.053"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304098"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307606"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305756"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c08912"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274\u2010021\u20103685\u20104"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202502322"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303078"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202406149"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmrt.2025.07.204"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.26599\/NR.2025.94907463"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5SC01799H"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202407046"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2019.100493"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c04378"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202406210"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202423015"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303958"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201501081"},{"key":"e_1_2_9_59_1","article-title":"Correlation of Blood and Salivary pH Levels in Healthy, Gingivitis, and Periodontitis Patients before and after Non\u2010Surgical Periodontal Therapy","volume":"12","author":"Koppolu P.","year":"2022","journal-title":"Diagnostics (Basel)"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c03544"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201045874\u2010z"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5c00393"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202423765"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202206368"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2024.11.007"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202317664"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201053824\u2010y"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201903981"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c13689"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201056179\u20100"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202408787"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202502147"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c04328"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.3c01923"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094499"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.158478"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202212566"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c05381"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123144"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2025.125256"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202519865","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202519865","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202519865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T10:03:02Z","timestamp":1771322582000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202519865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,26]]},"references-count":79,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/adma.202519865"],"URL":"https:\/\/doi.org\/10.1002\/adma.202519865","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,26]]},"assertion":[{"value":"2025-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e19865"}}