{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:49:23Z","timestamp":1782978563864,"version":"3.54.5"},"reference-count":51,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570363"],"award-info":[{"award-number":["82570363"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172074"],"award-info":[{"award-number":["82172074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82500380"],"award-info":[{"award-number":["82500380"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["25X010301348"],"award-info":[{"award-number":["25X010301348"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic heart failure (HF) remains a global health challenge due to the lack of therapies that effectively disrupt the pathological fibro\u2010inflammatory networks driving disease progression. While current nanomedicine strategies often target intracellular pathways in isolated cell types, they overlook the multicellular crosstalk central to HF. Here, we develop scalably synthesized Prussian blue (PB) nanoparticles that selectively intercept the CCL2\u2010CCR2 chemokine axis, a key pathway in fibroblast\u2010macrophage communication. Single\u2010nucleus RNA sequencing of murine and human failing hearts identifies a conserved pro\u2010fibroinflammatory cardiac fibroblast subpopulation (POSTN\n                    <jats:sup>hi<\/jats:sup>\n                    CCL2\n                    <jats:sup>hi<\/jats:sup>\n                    ) that recruits CCR2\n                    <jats:sup>+<\/jats:sup>\n                    macrophages via CCL2 secretion. PB nanoparticles exhibit ultrahigh affinity (K\n                    <jats:sub>D<\/jats:sub>\n                    = 1.11 \u00d7 10\n                    <jats:sup>\u221210<\/jats:sup>\n                    \u00a0\n                    <jats:sc>m<\/jats:sc>\n                    ) for free CCL2, inducing conformational distortion in its N\u2010terminal domain via specific C\u2261N interface interactions with CRS1 residues, thereby blocking CCR2 engagement, a mechanism distinct from conventional nanomaterials. Although ineffective in monocultures, PB nanoparticles robustly improve cardiac function and remodeling in murine and translational porcine pressure\u2010overload HF models, reducing left ventricular end\u2010diastolic volume by 56.2% and fibrosis by 40.5%, while selectively depleting CCR2\n                    <jats:sup>+<\/jats:sup>\n                    macrophages without systemic immunosuppression. Supported by scalable production (&gt; 100\u00a0g\/batch), long\u2010term stability, and biosafety, this work establishes a cell communication\u2010targeting nanomedicine strategy for network\u2010driven diseases like HF.\n                  <\/jats:p>","DOI":"10.1002\/adma.202520209","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:32:21Z","timestamp":1777098741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Nano\u2010Interception Strategy for Chronic Heart Failure: Prussian Blue Nanoparticles Disrupt Fibroblast\u2010Immune Communication via CCL2 Sequestration"],"prefix":"10.1002","volume":"38","author":[{"given":"Bo","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longming","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. 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