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Irreversible electroporation (IRE), a non\u2010thermal ablation technique, holds significant promise as it preserves critical peritumoral structures and can induce immunogenic cell death. However, the immunostimulatory effects elicited by IRE are typically transient, which constrains durable therapeutic benefit. To address this limitation, we developed an electro\u2010responsive nanoadjuvant system (PSFC) composed of peptide\u2010modified, superparamagnetic iron oxide (SPIO)\u2010encapsulated nanoparticles engineered to synergize with IRE. Upon IRE application, the PSFC nanoparticles undergo electro\u2010triggered disassembly, releasing CpG oligodeoxynucleotides (CpG ODNs) to amplify both innate and adaptive immune responses. This approach promotes antigen\u2010presenting cells\u2019 activation and macrophage polarization toward an M1 phenotype, while enhancing intratumoral T cell activation and pro\u2010inflammatory cytokine secretion. By enabling spatiotemporal control of immune activation, this combined electro\u2010immunotherapeutic strategy effectively overcomes the inherent immuno\u2010resistance of PDAC and yields significantly improved treatment outcomes.<\/jats:p>","DOI":"10.1002\/adma.202520546","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T04:16:28Z","timestamp":1773116188000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nanoadjuvant\u2010Mediated Electro\u2010Immunotherapy Enhances Irreversible Electroporation for Pancreatic Cancer Treatment"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9676-0384","authenticated-orcid":false,"given":"Chengyue","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ultrasound, School of Medicine, The First Affiliated Hospital Zhejiang University  Hangzhou 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