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Nanomaterials with characteristics such as chirality, 2D, and flexibility have attracted widespread attention because they can maximize the interface between the materials and immune cells. Here, we report the fabrication of 2\u2010D mesoporous silica nanodisks with a chiral meso\u2010topography as vaccine adjuvants. These uniform nanodisks, with diameters from 200\u00a0nm to 1 \u00b5m, possess unique spiral mesoporous patterns of \u223c 10\u00a0nm. The thickness of the chiral mesoporous nanodisks can be precisely controlled in units of one layer (\u223c 7\u00a0nm), thereby achieving precise regulation in surface topology, dimension and flexibility. The unique 2\u2010D chiral mesoporous structure originates from the maximum occupancy of confined space of micellar helical arrangement, which is distinct from conventional methods based on internal tension. The combination of flexibility, 2\u2010D structure and chirality enhances nanodisks\u2019 interaction with dendritic cells (DCs), significantly improving DC maturation via Toll\u2010like receptors\/Nuclear Factor\u2010kappa B (TLR\/NF\u2010\u03baB), Mitogen\u2010Activated Protein Kinase (MAPK) and Focal Adhesion Kinase (FAK) signaling pathways. Upon nanovaccines\u2019 activation of DCs in vivo, DCs further presents antigen for activating T cells to trigger balanced cellular and humoral immunity. Subcutaneous injection of the nanodisks\u2010adjuvanted cancer vaccine can significantly inhibit the tumor growth and extend the survival of melanoma\u2010bearing mice to more than 60 days, about three times higher than that of the PBS\u2010treated group. When combined with PD\u20101 antibody, the cancer vaccines maximize tumor suppression, achieving a tumor\u2010free outcome in one\u2010third of the cases.<\/jats:p>","DOI":"10.1002\/adma.202520552","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:29:03Z","timestamp":1768807743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Self\u2010Assembled Two\u2010Dimensional Chiral Meso\u2010Topography Determines the Balance of Cellular and Humoral Immunity Against Tumors"],"prefix":"10.1002","volume":"38","author":[{"given":"Lingkai","family":"Dong","sequence":"first","affiliation":[{"name":"College of Smart Materials and Future Energy Department of Chemistry Fudan University  Shanghai P. R. 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