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Innovative, safe, and therapeutically adaptive strategies are urgently required to combat antimicrobial resistance (AMR) pathogens. A glucose\u2010oxidase conjugated cerium oxide nanoparticle (CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs\u2010GOx)\u2010based nanozyme displaying oxidase\u2010mimetic activity at physiological pH and wound exudate is developed. The conjugate displays potent antibacterial activity and eradication of \u03b2\u2010lactamase\u2010producing clinical isolates of methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) by producing superoxide and hydroxyl radicals in the presence of adenosine triphosphate (ATP) and glucose. Microscopic imaging, lactate dehydrogenase (LDH) release and lipid peroxidation assays revealed compromised bacterial cell wall structure and release of cytoplasmic contents due to the continuous production of free radicals. The in vivo MRSA\u2010infected wound data showed that application of CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs\u2010GOx led to infection clearance within a week, as well as better wound closure than vancomycin. Upon CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs\u2010GOx treatment, wound tissues undergo enhanced re\u2010epithelialization, collagen deposition, and angiogenesis, while reduced production of pro\u2010inflammatory cytokines (IL\u20106, TNF\u2010\u03b1, and IL\u20101\u03b2). CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs\u2010GOx exposure displayed almost no accumulation rather rapid clearance of nanozymes\u00a0from the body. Overall, this study establishes CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs\u2010GOx as an effective antibacterial nanozyme, integrating ATP\u2010assisted oxidase\u2010mimetic activity, exhibiting reactive oxygen species (ROS)\u2010mediated elimination of MRSA infection from wounds. Thus, the developed novel CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs\u2010based nanozyme offers an alternative to antibiotics for clinical translation and effective control of AMR spread.\n                  <\/jats:p>","DOI":"10.1002\/adma.202520966","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:23:48Z","timestamp":1779103428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Glucose\u2010Oxidase Conjugated Cerium Oxide\u2010Based Super Nanozyme for Rapid MRSA Eradication and Wound Closure"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6674-8480","authenticated-orcid":false,"given":"Divya","family":"Mehta","sequence":"first","affiliation":[{"name":"Nanobiology and Nanozymology Research Laboratory BRIC\u2010National Institute of Animal Biotechnology (NIAB)  Hyderabad Telangana India"},{"name":"DBT\u2010Regional Centre for Biotechnology (RCB)  Faridabad Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuti","family":"Bhagat","sequence":"additional","affiliation":[{"name":"Nanobiology and Nanozymology Research Laboratory BRIC\u2010National Institute of Animal Biotechnology (NIAB)  Hyderabad Telangana India"},{"name":"DBT\u2010Regional Centre for Biotechnology (RCB)  Faridabad Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6256-7091","authenticated-orcid":false,"given":"Sanjay","family":"Singh","sequence":"additional","affiliation":[{"name":"Nanobiology and Nanozymology Research Laboratory BRIC\u2010National Institute of Animal Biotechnology (NIAB)  Hyderabad Telangana India"},{"name":"DBT\u2010Regional Centre for Biotechnology (RCB)  Faridabad Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"StatPearls","author":"Siddiqui A. 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