{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:04:20Z","timestamp":1784297060089,"version":"3.55.0"},"reference-count":52,"publisher":"Wiley","issue":"40","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The persistent burden of respiratory viruses requires rapid, simple, and robust screening and environmental surveillance technologies that enable widespread and frequent testing. Importantly, these technologies should be based on infectivity\u2010relevant signals, as RNA detection alone has limited correlation with transmission risk. Here, we present a membrane fusion\u2010mediated platform that autonomously detects viruses by recapitulating the native viral entry mechanism. Fusogenic vesicles selectively fuse with fusion\u2010competent viral particles, triggering encapsulated CRISPR\u2010Cas13a components to generate fluorescent signals upon recognition of the released viral RNA. Through an autonomous workflow and accelerated signal generation within a confined vesicle, our platform achieves one\u2010step detection of viruses within 2 min. The assay robustly detects three major respiratory viruses, with analytical sensitivities down to 5 TCID\n                    <jats:sub>50<\/jats:sub>\n                    \/mL for RSV and 50 TCID\n                    <jats:sub>50<\/jats:sub>\n                    \/mL for SARS\u2010CoV\u20102 and IAV. Clinical validation with 100 nasopharyngeal samples achieved 91.7% sensitivity. Remarkably, the sprayable format enables large\u2010area surveillance of surface contamination\u2014like luminol revealing hidden bloodstains, it makes invisible viral threats visible. This approach establishes an intuitive real\u2010time detection platform, extending beyond clinical specimens to encompass environmental threats.\n                  <\/jats:p>","DOI":"10.1002\/adma.202521241","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T06:07:31Z","timestamp":1775628451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Viral Infection\u2010Inspired Autonomous Detection of Fusion\u2010Competent Viruses for Screening and Environmental Surveillance"],"prefix":"10.1002","volume":"38","author":[{"given":"Jae Chul","family":"Park","sequence":"first","affiliation":[{"name":"Center for Advanced Biomolecular Recognition Korea Institute of Science and Technology (KIST)  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidam","family":"Song","sequence":"additional","affiliation":[{"name":"Center for Advanced Biomolecular 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye\u2010Jun","family":"Jo","sequence":"additional","affiliation":[{"name":"Division of Emerging Infectious Diseases Korea Disease Control and Prevention Agency (KDCA)  Cheongju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jahyun","family":"Koo","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Korea University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngdo","family":"Jeong","sequence":"additional","affiliation":[{"name":"Center for Advanced Biomolecular Recognition Korea Institute of Science and Technology (KIST)  Seoul Republic of Korea"},{"name":"Department of HY\u2010KIST Bio\u2010Convergence Hanyang University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan Hyi","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Advanced 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