{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:17:41Z","timestamp":1789647461141,"version":"4.0.0"},"reference-count":98,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52225302"],"award-info":[{"award-number":["52225302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402813"],"award-info":[{"award-number":["82402813"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372413"],"award-info":[{"award-number":["82372413"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92468205"],"award-info":[{"award-number":["92468205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M751838"],"award-info":[{"award-number":["2024M751838"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Despite the persistence of spared spinal circuits capable of relaying commands after spinal cord injury (SCI), their contribution to recovery remains constrained by functional dormancy of spared neurons and impaired reconnection across the lesion. Serotonergic neuromodulation is pivotal for reactivating dormant neurons, however, achieving precise targeting and modulation of the serotonergic system poses translational challenges. Here, a DNA\/RNA heteroduplex hydrogel is reported that integrates 5\u2010hydroxytryptamine (5\u2010HT)\u2010mediated neuronal excitability restoration with phosphatase and tensin homolog (PTEN)\u2010targeted spinal circuit reconstruction for SCI therapy. The 5\u2010hydroxytryptophan (5\u2010HTP)\u2010derived motif, serving both as a targeting ligand and as a neuromodulator, is site\u2010specifically grafted onto three phosphorothioate\u2010bearing single\u2010stranded DNA (ssDNA) strands, which self\u2010assemble into Y\u2010shaped motifs and are subsequently crosslinked by sticky\u2010ended PTEN small interfering RNA (siRNA) to form the hydrogel network. After lesion\u2010site administration, the hydrogel undergoes DNase\u2010mediated network disassembly into nanogels that exert two complementary therapeutic actions by targeting serotonergic system: restoring excitability to reactivate dormant interneurons and reconstructing descending connectivity to reintegrate spared circuits with the host spinal cord, thereby restoring sensory and locomotor functions in paralyzed mice. This strategy coordinately reinstates functional excitability and structural rebuilding by engaging multiple interlocking mechanisms, advancing a versatile paradigm for integrative therapy of central nervous system (CNS) disorders.<\/jats:p>","DOI":"10.1002\/adma.202521427","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T07:24:24Z","timestamp":1768375464000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serotonergic System\u2010Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9668-2346","authenticated-orcid":false,"given":"Chunlin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine Shandong University  Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine Shandong University  Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University  800 Dongchuan Road Shanghai P. R. China"},{"name":"Department of Ophthalmology, Eye &amp; ENT Hospital, State Key Laboratory of Brain Function and Disorders Fudan University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery and Transplantation and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Liver Cancer Institute Zhongshan Hospital Fudan University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Qilu Hospital of Shandong University  Wenhuaxi Road 107 Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine Shandong University  Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoshuai","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine Shandong University  Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haonan","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University  800 Dongchuan Road Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine Shandong University  Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglei","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University  800 Dongchuan Road Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine Shandong University  Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenbo","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine Shandong University  Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghui","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine Shandong University  Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Second Qilu Hospital of Shandong University, Cheeloo College of Medicine Shandong University  Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangchuang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine Shandong University  Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, Shanghai Jiao Tong University Affiliated Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiquan","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine Shandong University  Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University  800 Dongchuan Road Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqing","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine Shandong University  Jinan Shandong P. R. China"},{"name":"Department of Orthopaedics, The Second Qilu Hospital of Shandong University, Cheeloo College of Medicine Shandong University  Jinan Shandong P. R. China"},{"name":"Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin Medical University International Science and Technology Cooperation Base of Spinal Cord Injury Tianjin Key Laboratory of Spine and Spinal Cord  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0053-8970","authenticated-orcid":false,"given":"Hengxing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine Shandong University  Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01196-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01477-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90608"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adi6412"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00562-y"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60547-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-023-01416-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0467-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2603"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.18"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-44898-9"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06094-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2019"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2608"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.29.051605.112910"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2160"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2014.00151"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2020.00014"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27419-w"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01186-3"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01213-3"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.10.075"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.27.070203.144206"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-6997(24)01478-9"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-020-0314-2"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4232706"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ads4938"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20703-1"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202505402"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1217416"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.11.019"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00464-6"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.10.029"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1161566"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00885-4"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1501441112"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02668-0"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202308110"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01589-z"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau0159"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.2c00441"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00162-z"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0017-4"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-070918-050501"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010919-023738"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202013243"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0075-7"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-021-00439-4"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00373"},{"key":"e_1_2_8_52_1","first-page":"860","article-title":"Enhanced delivery of antibodies across the blood\u2010brain barrier via TEMs with inherent receptor\u2010mediated phagocytosis","volume":"3","author":"Edavettal S.","year":"2022","journal-title":"Med (New York, NY)"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2007.07.011"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.04.012"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.199"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb4429"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn2941"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn1000205"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306248"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01067-9"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.06.004"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.02.012"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202411628"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36587-w"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.98"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae100"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0207-x"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/416636a"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309305"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307624"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202502795"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2019.09.004"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31797-0"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2795-6"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1802-z"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00173-X"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.13004\/kjnt.2022.18.e21"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4192"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50564-x"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13974"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1326"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.08.020"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.07.007"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2482"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(00)00402-0"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97837"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ado9120"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.355763"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/app11094097"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40634-017-0105-5"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-083122-025325"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19914-3"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.9"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00203"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00042.2008"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202204528"},{"key":"e_1_2_8_99_1","doi-asserted-by":"crossref","unstructured":"A. E.Ropper D. K.Thakor andI.Han \u201cDefining recovery neurobiology of injured spinal cord by synthetic matrix\u2010assisted hMSC implantation \u201d inProceedings of the National Academy of Sciences of the United States of America(2017) E820\u2013E829.","DOI":"10.1073\/pnas.1616340114"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202521427","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202521427","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202521427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:44:22Z","timestamp":1783115062000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202521427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,13]]},"references-count":98,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/adma.202521427"],"URL":"https:\/\/doi.org\/10.1002\/adma.202521427","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,13]]},"assertion":[{"value":"2025-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e21427"}}