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Given the diversity of chemical neurotransmitters and ion species, developing an artificial chemo\u2010ionic cascade synapse that can translate biochemical signals into tunable synaptic weights will be of great significance for brain\u2010inspired computing and brain\u2010computer interfaces. Here, we present an artificial dopamine (DA)\u2010ionic cascade synapse by integrating a sensitive DA sensor with an ionic elastomer\u2010based neuromorphic device. The oxidation of DA generates localized electric fields that electrostatically modulate ion migration within the ionic elastomer device, enabling chemical\u2010to\u2010ionic signal transduction and dynamic plasticity control. Consequently, biochemical cues like DA concentration can be directly reflected in tunable ionic synaptic weights, which can then be used to control a robotic platform for recognition tasks. This artificial synapse exhibits biochemical signal\u2010driven behavioral selectivity in an object\u2010grasping task, completing a perception\u2010decision\u2010execution loop. This work establishes a framework for processing biochemical information via native ionic dynamics, paving the way for chemically neuromorphic systems and embodied human\u2010machine interaction.<\/jats:p>","DOI":"10.1002\/adma.202521464","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T09:18:58Z","timestamp":1776244738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["An Artificial Dopamine\u2010Ionic Cascade Synapse for Adaptive Neuromorphic Attention"],"prefix":"10.1002","volume":"38","author":[{"given":"Hongjie","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau  Macau P. R. 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