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Although nitric oxide (NO) holds promise for its anti\u2010inflammatory and regenerative properties, its clinical translation is limited by a short half\u2010life and uncontrolled release,\u00a0failing to match chronic diabetic bone repair.\u00a0Herein,\u00a0we present an MP\u2010LAS scaffold based on a micropore\u2010confinement strategy, which transforms release kinetics from a \u201cburst\u2010exhaustion\u201d mode to a sustained, on\u2010demand output.\u00a0The scaffold is fabricated by 3D printing coupled with phase separation, featuring a core of ROS\u2010degradable hydrogel loaded with L\u2010arginine (L\u2010Arg) and a shell of nano\u2010hydroxyapatite\/polycaprolactone (nHA\/PCL) with interconnected microporosity. The well\u2010designed micropores\u00a0precisely confine the ROS\/L\u2010Arg reaction,\u00a0triggering localized degradation of the core and controllable L\u2010Arg release for subsequent in situ NO generation.\u00a0This system maintains a stable NO supply for 3 months, avoiding burst\u2010release toxicity while continuously neutralizing pathological ROS.\u00a0Both in vitro and in vivo evaluations demonstrate that\u00a0this dual action synergistically modulates macrophage M2 polarization, angiogenesis, and osteogenic differentiation,\u00a0ultimately facilitating diabetic bone regeneration\u00a0via NO\u2010mediated vascular\u2010osteogenic coupling.\u00a0This work offers\u00a0a novel, versatile micropore\u2010confined platform for precise molecule delivery in complex pathological microenvironments.<\/jats:p>","DOI":"10.1002\/adma.202521475","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:36:10Z","timestamp":1772966170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Micropore\u2010Confined ROS\u2010Responsive 3D\u2010Printed Shell\u2010Core Scaffolds for Long\u2010Term NO Release to Orchestrate Immunomodulation and Angiogenesis in Diabetic Bone Defect Repair"],"prefix":"10.1002","volume":"38","author":[{"given":"Jiali","family":"Guo","sequence":"first","affiliation":[{"name":"Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging Department of Biomedical Engineering Shenzhen University Medical School Shenzhen University  Shenzhen China"},{"name":"Research Center for Human Tissue and Organ Degeneration Institute of Biomedicine and Biotechnology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  Shenzhen 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