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Here, we introduce a strategy for post\u2010fabrication engineering of a custom protein corona on mRNA\u2010LNPs using cationic silk fibroin (SF), a biocompatible and chemically tunable protein polymer. SF\u2010coated LNPs exhibit enhanced cellular uptake and endosomal escape, resulting in a 3.6 fold increase in lymph node delivery and a 2.5 fold extension in in vivo protein expression compared to unmodified LNPs. In a cancer vaccine model, SF\u2010LNPs significantly improve dendritic cell maturation, antigen cross\u2010presentation, and cytotoxic T cell activation, leading to robust protection against tumor growth and metastasis, as well as durable immunological memory. 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