{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:23:32Z","timestamp":1792135412374,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"51","license":[{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["PID2023\u2010152920NB\u2010I00 CEX2024\u2010001467\u2010M"],"award-info":[{"award-number":["PID2023\u2010152920NB\u2010I00 CEX2024\u2010001467\u2010M"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["CIPROM\/2022\/48"],"award-info":[{"award-number":["CIPROM\/2022\/48"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","award":["PRTR\u2010C17.I1"],"award-info":[{"award-number":["PRTR\u2010C17.I1"]}],"id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The direct synthesis of high\u2010valence metal\u2013organic frameworks (HV\u2010MOFs) under biocompatible conditions remains an outstanding challenge due to the strong Lewis acidity and sluggish coordination kinetics of their metal centers. Here, we report a mild, aqueous synthesis of UiO\u201066\u2014a benchmark Zr\n                    <jats:sup>4<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    \u2010based framework\u2014using the conventional benzene dicarboxylic acid (H\n                    <jats:sub>2<\/jats:sub>\n                    BDC) linker. The approach enables the formation of highly crystalline protein@UiO\u201066 composites while preserving biomolecule integrity and activity. In situ SAXS and cryoEM reveal that protein incorporation modulates prenucleation and growth dynamics, providing mechanistic insight into how the Lewis acidity of Zr\n                    <jats:sup>4<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    governs framework assembly and biomolecule confinement. This work establishes a direct, biocompatible route to UiO\u201066 and elucidates fundamental principles underlying MOF\u2013biomolecule co\u2010assembly in highly Lewis\u2010acidic systems, advancing the design of robust biointegrated hybrid materials.\n                  <\/jats:p>","DOI":"10.1002\/adma.202521603","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T15:50:08Z","timestamp":1774713008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Direct Synthesis of High\u2010Valence Protein@UiO\u201066 Composites: Linking Crystallization Pathways to Protein Encapsulation"],"prefix":"10.1002","volume":"38","author":[{"given":"Jes\u00fas Cases","family":"D\u00edaz","sequence":"first","affiliation":[{"name":"Instituto de Ciencia Molecular (ICMol) Universidad de Valencia Paterna Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Glatz","sequence":"additional","affiliation":[{"name":"Instituto de Ciencia Molecular (ICMol) Universidad de Valencia Paterna Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa Merced","family":"Olivas","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of California  Irvine California USA"},{"name":"Department of Materials Science and Engineering University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Pons","sequence":"additional","affiliation":[{"name":"Institute for Advanced Chemistry of Catalonia (IQAC\u2010CSIC)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Patterson","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of California  Irvine California USA"},{"name":"Department of Materials Science and Engineering University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4931-5711","authenticated-orcid":false,"given":"M\u00f3nica","family":"Gim\u00e9nez\u2010Marqu\u00e9s","sequence":"additional","affiliation":[{"name":"Instituto de Ciencia Molecular (ICMol) Universidad de Valencia Paterna Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01029"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202001648"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7cs00058h"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201916474"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c07107"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl5026419"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8240"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja513058h"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.7b04977"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c13525"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC00825F"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00905a001"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c04137"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.2c01338"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c07785"},{"key":"e_1_2_10_17_1","article-title":"A 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