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Here, we show a pioneering approach that leverages sacrificial nitric oxide (NO) to enhance hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) retention for antibiofilm therapy. H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    has the ability to produce hydroxyl radicals (\u2022OH), the most potent oxidants in nature, but it is often neutralized by H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    scavengers before \u2022OH formation. Our design utilizes ultrasound irradiation to release NO from the biofilm\u2010anchoring nano\u2010xanthiums (G\u2010B@NXs), which subsequently interact with biofilm\u2010associated H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    scavengers, including catalase and glutathione, to suppress the decomposition ability toward H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . Additionally, glucose oxidase on the surface of G\u2010B@NXs supplements H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    production, facilitates its conversion into \u2022OH, and exhibits effective biofilm sterilization in different infection models. Our strategy not only shows the promise for advancing antibiofilm applications but also provides novel insights into the development of NO\u2010assisted biomaterials.\n                  <\/jats:p>","DOI":"10.1002\/adma.202521809","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T10:21:54Z","timestamp":1766744514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sacrificing Knight for Pawn\u2010Queen Promotion: Sonosensitive Nano\u2010Xanthiums Orchestrate NO to Retain H\n                    <sub>2<\/sub>\n                    O\n                    <sub>2<\/sub>\n                    for Antibiofilm Therapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Yuzheng","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Physics Department of Materials Science and Engineering and Department of Biomedical Engineering City University of Hong Kong  Kowloon Hong 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