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However, conventional metal\u2010insulator\u2010metal (MIM) metasurface resonators exhibit inherently limited Q\u2010factor and sensitivity due to radiative leakage through open side boundaries. Here, a lattice slot waveguide based on MIM configuration is designed to effectively confine energy within the microfluidic channel and mitigate radiative loss. This trapped mode achieves enhanced sensitivity and Q\u2010factor through synergistic excitation of surface lattice resonance and guided mode resonance under propagation constant matching conditions. Leveraging this platform, an anisotropic detection strategy incorporating a patterned lattice structure is devised to achieve simultaneous polarization multiplexed responses, exhibiting a figure of merit of 135 in both polarizations. Experimental validation demonstrates a limit of detection of 625\u00a0pmol\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    and a Q\u2010factor of 189 for this polarization multiplexing microfluidic platform. This work offers a unique avenue for enhanced accuracy and efficiency in terahertz biomedical trace analyzing via multidimensional sensing capabilities.\n                  <\/jats:p>","DOI":"10.1002\/adma.202521964","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T07:00:11Z","timestamp":1770620411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lattice Slot Waveguide for Terahertz Microfluidics Biomedical Trace Analysis"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5747-1151","authenticated-orcid":false,"given":"Shui","family":"Liu","sequence":"first","affiliation":[{"name":"College of Electronic and Optical Engineering &amp; College of Flexible Electronics (Future Technology) Nanjing University of Posts and Telecommunications  Nanjing China"},{"name":"State Key Laboratory of Millimeter Waves Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Electronic and Optical Engineering &amp; 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