{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:33:32Z","timestamp":1792607612372,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52293381"],"award-info":[{"award-number":["52293381"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52473152"],"award-info":[{"award-number":["52473152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pyroptosis, an immunogenic programmed cell death, is a robust way to activate anti\u2010cancer immunity. However, it is very challenging to induce pyroptosis in cancer cells while sparing normal cells selectively. Herein, an Er\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010containing nanoparticle is screened from the whole series of lanthanides for boosting pancreatic cancer immunotherapy by selectively inducing cancer cell pyroptosis. To elicit tumor\u2010specific inflammatory cell death, a tumor\u2010targeting nanoplatform, termed the Erbium\u2212RSL3 Inflammasome\u2010Activating System (ERIS), was designed, invoking the \u201cGreek goddess of discord\u201d to unleash discord within tumors. ERIS has been proven to induce pyroptosis through lysosomal rupture, facilitated by a strong interaction between Er\n                    <jats:sup>3+<\/jats:sup>\n                    and lysosomal phospholipid membranes, as evidenced by a 3.2\u2010fold increase in GSDMD\u2010N cleavage and a 12.2\u2010fold increase in lactate dehydrogenase (LDH) release compared with controls. This localized inflammatory assault subverts tumor growth and promotes anti\u2010cancer immune responses. Therefore, ERIS demonstrates remarkable tumor suppression with minimal systemic side effects across different pancreatic cancer models, achieved through pyroptosis\u2010induced immune activation and remodeling of the immunosuppressive tumor microenvironments. This study identifies Er\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010based nanomedicine as a new class of cell\u2010selective pyroptosis nanotuner, offering a unique opportunity to enhance the efficacy of cancer immunotherapies.\n                  <\/jats:p>","DOI":"10.1002\/adma.202522094","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:26:47Z","timestamp":1774870007000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Selective Induction of Cancer Cell Pyroptosis by Erbium Nanotuner Enhances Potent Anti\u2010Cancer Immunity"],"prefix":"10.1002","volume":"38","author":[{"given":"Wenbin","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Polymer Science and Engineering Zhejiang University 866 Yuhangtang Road Hangzhou 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