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However, high\u2010dose radiation often triggers DNA repair mechanisms, undermining therapeutic efficacy and causing damage to surrounding healthy tissues. Thus, enhancing anti\u2010tumor effects at lower doses while minimizing normal tissue damage and improving safety remains a key challenge in advancing RT technologies. To tackle these issues, we developed an RT\u2010sensitizing platform, referred to as HAEPRC, which integrates a novel high\u2010entropy alloy (HEA) composed of gold (Au), bismuth (Bi), platinum (Pt), silver (Ag), and palladium (Pd), a CRISPR\/Cas9 gene\u2010editing system, and tumor cell membranes (CM) for enhanced home\u2010targeting and biocompatibility. We demonstrated that HAEPRC exhibits exceptional dose enhancement factors (DEFs), significantly boosting RT sensitization and improving RT\u2010induced immunotherapeutic outcomes. Furthermore, the gene\u2010editing system modulates the cell cycle, transforming RT\u2010resistant cancer cells into RT\u2010sensitive ones and further amplifying RT efficacy. Additionally, Pd\u2010mediated bioorthogonal catalysis activates immune adjuvant production, enhancing immune responses and reinforcing anti\u2010tumor immunity. Collectively, these features synergistically promote an enhanced abscopal immune effect, inhibiting lung cancer growth and metastasis, and providing a promising strategy to improve the efficacy and safety of RT.<\/jats:p>","DOI":"10.1002\/adma.202522618","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:05:16Z","timestamp":1774951516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High\u2010Entropy Alloy Synergized with Gene Editing for Cocktail\u2010Sensitized Radioimmunotherapy of Lung Metastases"],"prefix":"10.1002","volume":"38","author":[{"given":"Qianglan","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Gastric and Hernia Surgery Nanjing Drum Tower Hospital College of Engineering and Applied Sciences State Key Laboratory of Analytical Chemistry for Life Science Nanjing University  Nanjing P. R. 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