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Current therapies are limited by diagnostic inaccuracy, incomplete biofilm elimination, and inadequate tissue regeneration. To address these challenges, an injectable theranostic Ce6@PEG\u2010MoO\n                    <jats:sub>x<\/jats:sub>\n                    \u2010loaded hydrogel through facile construction is proposed, encompassing an intelligent closed\u2010loop for comprehensive periodontitis management. After being injected into periodontal pockets, the hydrogel adheres to tissues and responds to microenvironmental MMPs, realizing on\u2010demand therapeutic release. By integrating photoacoustic imaging, the hydrogel facilitates noninvasive, precise and reproducible measurement of porcine periodontal pocket depths, enabling periodontitis diagnosis and monitoring. Subsequently, released oxygen\u2010vacancy\u2010rich MoO\n                    <jats:sub>x<\/jats:sub>\n                    nanozyme mitigates cellular oxidative stress, generates O\n                    <jats:sub>2<\/jats:sub>\n                    to enhance Ce6\u2010mediated photodynamic eradication of deep\u2010seated biofilms, and scavenges residual ROS after bactericidal process. Notably, this system avoids off\u2010target ROS generation and photothermal damage, preserving surrounding tissues including dental pulp, thus exhibiting exceptional light\u2010controlled ROS\u2010modulation. Furthermore, released Mo activates the PI3K\/AKT pathway to upregulate angiogenic factors, reprograms M2 macrophages polarization, and stimulates osteogenesis of periodontal stem cells. Altogether, this self\u2010adaptive ecosystem integrates diagnosis, monitoring, biofilm debridement, and tissue regeneration, establishing a closed\u2010loop precision therapy for periodontitis with significant clinical potential.\n                  <\/jats:p>","DOI":"10.1002\/adma.202522859","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T06:22:50Z","timestamp":1770186170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A Self\u2010Adaptive Periodontal Ecosystem Engineered With Molybdenum\u2010Based Nanozyme\u2010Embedded Composite Hydrogel for Microenvironment\u2010Responsive Precision Therapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Zeman","family":"Qin","sequence":"first","affiliation":[{"name":"Hospital of Stomatology Guangdong Provincial Key Laboratory of Stomatology Institute of Stomatological Research Guanghua School of Stomatology Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqian","family":"You","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology Guangdong Provincial Key Laboratory of Stomatology Institute of Stomatological Research Guanghua School of Stomatology Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyi","family":"Wu","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology Guangdong Provincial Key Laboratory of Stomatology Institute of Stomatological Research Guanghua School of Stomatology Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abudusaimi","family":"Maimaiti","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology Guangdong Provincial Key Laboratory of Stomatology Institute of Stomatological Research Guanghua School of Stomatology Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarun","family":"Li","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology Guangdong Provincial Key Laboratory of Stomatology Institute of Stomatological Research Guanghua School of Stomatology Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2470-6713","authenticated-orcid":false,"given":"Qinmei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine First Affiliated Hospital Sun Yat\u2010sen University; Biomaterial group NHC Key Laboratory of Assisted Circulation and Vascular Diseases Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Teng","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology Guangdong Provincial Key Laboratory of Stomatology Institute of Stomatological Research Guanghua School of Stomatology Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31146-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c01940"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.01.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513490168"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.38"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345221102084"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111558"},{"key":"e_1_2_8_9_1","volume-title":"Periodontology for the Dental Hygienist","author":"Perry D. 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