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In this work, we develop a hybridized cell membrane of glioma\u2010macrophage cells (GMM) camouflaged bi\u2010target nanomodulator (LNO@CH\/Ca\n                    <jats:sub>3<\/jats:sub>\n                    (PO\n                    <jats:sub>4<\/jats:sub>\n                    )\n                    <jats:sub>2<\/jats:sub>\n                    , LCC) comprised of LaNiO\n                    <jats:sub>3<\/jats:sub>\n                    (LNO) core and Ca\n                    <jats:sub>3<\/jats:sub>\n                    (PO\n                    <jats:sub>4<\/jats:sub>\n                    )\n                    <jats:sub>2<\/jats:sub>\n                    shell loaded with the aryl hydrocarbon receptor (AhR) antagonist (CH223191, CH), which can synergistically modulate glioma\u2010associated myeloid cells (GAM) polarization by inducing pyroptosis and regulating tryptophan metabolism to enhance the efficacy of IDH\u2010mutant gliomas immunotherapy. The hybrid cell membrane endows LCC@GMM with good blood brain barrier (BBB) penetration as well as dual homing ability to tumor cells and GAM. LCC@GMM not only induces pyroptosis in tumor cells by the production of cytotoxic reactive oxygen species (ROS) and the released La\n                    <jats:sup>3<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    but also regulates tryptophan metabolism in GAM via the released CH, effectively overcoming the immunosuppressive effects of IDH\u2010mutant gliomas. The bi\u2010target synergistic regulation of GAM reshapes the immunosuppressive TME of IDH\u2010mutant gliomas and offers a novel idea for immunotherapy of IDH\u2010mutant gliomas.\n                  <\/jats:p>","DOI":"10.1002\/adma.202523021","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T11:02:06Z","timestamp":1774090926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Bi\u2010Target Nanomodulator for Glioma\u2010Associated Myeloid Cells Polarization by Inducing Pyroptosis and Regulating Tryptophan Metabolism to Reshape Immunosuppressive Microenvironment of IDH\u2010Mutant Gliomas"],"prefix":"10.1002","volume":"38","author":[{"given":"Shiqi","family":"Bai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry (CIAC) Chinese Academy of Sciences  Changchun China"},{"name":"Genetic 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