{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:50:53Z","timestamp":1791910253788,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"57","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFB3205602"],"award-info":[{"award-number":["2022YFB3205602"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52372174"],"award-info":[{"award-number":["52372174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82230030"],"award-info":[{"award-number":["82230030"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["T2125003"],"award-info":[{"award-number":["T2125003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The clinical efficacy of platinum\u2010based chemotherapeutics is frequently diminished by the emergence of resistance during prolonged treatment. Cisplatin (DDP)\u2010resistant tumors adapt to chemotherapeutic stress by establishing a new state of adaptive homeostasis that sustains cellular survival under drug pressure, albeit at the expense of high metabolic burden and acquired vulnerability. Exploiting this intrinsic weakness, we designed a DDP\u2010doped black phosphorus (BP) nanomedicine protected by polydopamine coating (DDP\u2010BP@PDA) that synergistically delivered DDP and piezoelectric BP to precisely disrupt resistance homeostasis and thereby reverse DDP resistance. DDP\u2010BP@PDA altered the intracellular uptake pathway of DDP and disrupted the redox balance of resistant cells via piezocatalysis. Concurrently, piezoelectric polarization enhanced the peroxidase\u2010like activity via electron injection, leading to the generation of substantial reactive oxygen species (ROS). This ROS burst compromised the integrity of the endoplasmic reticulum (ER) membrane and exacerbated the protein\u2010folding burden, thereby amplifying ER stress. Mechanism study reveals that excessive ER stress downregulated the expression of DNA repair proteins, making resistant cells highly sensitive to DDP\u2010induced DNA damage. Through these synergistic effects, DDP\u2010BP@PDA disrupted the adaptive homeostasis of DDP\u2010resistant cells, thereby significantly inhibiting the progression of DDP\u2010resistant tumors. This study establishes a promising therapeutic strategy to combat DDP\u2010resistance via piezoelectric\u2010driven disruption of adaptive homeostasis.<\/jats:p>","DOI":"10.1002\/adma.202523163","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:51:31Z","timestamp":1786956691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cisplatin\u2010Doped Black Phosphorus Nanomedicines Overcome Platinum\u2010Based Anticancer Drug Resistance via Piezoelectric\u2010Mediated Adaptive Homeostasis Disruption"],"prefix":"10.1002","volume":"38","author":[{"given":"Yijie","family":"Fan","sequence":"first","affiliation":[{"name":"Beijing Institute of Nanoenergy and Nanosystems Beijing Key Laboratory of High\u2010Entropy Energy Materials and Devices Chinese Academy of Sciences  Beijing P. R. China"},{"name":"School of Nanoscience and Engineering University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Nanoenergy and Nanosystems Beijing Key Laboratory of High\u2010Entropy Energy Materials and Devices Chinese Academy of Sciences  Beijing P. R. China"},{"name":"School of Nanoscience and Engineering University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Nanoenergy and Nanosystems Beijing Key Laboratory of High\u2010Entropy Energy Materials and Devices Chinese Academy of Sciences  Beijing P. R. China"},{"name":"School of Nanoscience and Engineering University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Nanoenergy and Nanosystems Beijing Key Laboratory of High\u2010Entropy Energy Materials and Devices Chinese Academy of Sciences  Beijing P. R. China"},{"name":"School of Nanoscience and Engineering University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizeng","family":"Luo","sequence":"additional","affiliation":[{"name":"Beijing Institute of Nanoenergy and Nanosystems Beijing Key Laboratory of High\u2010Entropy Energy Materials and Devices Chinese Academy of Sciences  Beijing P. R. China"},{"name":"School of Nanoscience and Engineering University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Ren","sequence":"additional","affiliation":[{"name":"Beijing Institute of Nanoenergy and Nanosystems Beijing Key Laboratory of High\u2010Entropy Energy Materials and Devices Chinese Academy of Sciences  Beijing P. R. China"},{"name":"School of Nanoscience and Engineering University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Li","sequence":"additional","affiliation":[{"name":"Vita Tech Innovation Center School of Clinical Medicine Beijing Tsinghua Changgung Hospital Tsinghua University  Beijing P. R. China"},{"name":"School of Biomedical Engineering Tsinghua University  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Nanoenergy and Nanosystems Beijing Key Laboratory of High\u2010Entropy Energy Materials and Devices Chinese Academy of Sciences  Beijing P. R. China"},{"name":"School of Nanoscience and Engineering University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4657-6131","authenticated-orcid":false,"given":"Dan","family":"Luo","sequence":"additional","affiliation":[{"name":"Beijing Institute of Nanoenergy and Nanosystems Beijing Key Laboratory of High\u2010Entropy Energy Materials and Devices Chinese Academy of Sciences  Beijing P. R. China"},{"name":"School of Nanoscience and Engineering University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1123"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079\u2010017\u20100435\u20101"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2692"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.111.005637"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.04.012"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.07.025"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13070778"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239248"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00261"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1419468"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201014928\u20103"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr4006236"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3800"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b01143"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2015.06.027"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201800510"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201024079\u20108"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201505281"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201807279"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201401437"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202001976"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202101467"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201903427"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c02186"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202317220"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr020010d"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.04.011"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201603276"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.03.015"},{"key":"e_1_2_8_31_1","first-page":"1","volume":"27","author":"Sassano M. L.","year":"2025","journal-title":"Nature Cell Biology"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201049597\u2010z"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.66630"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.15.6773\u20106787.2004"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476\u20104598\u20109\u2010248"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c02149"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0909049505012719"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0909049500016290"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1103\/RevModPhys.72.621"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.15541\/jim20200703"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1995.134"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202523163","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202523163","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202523163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:13:43Z","timestamp":1791908023000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202523163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":40,"journal-issue":{"issue":"57","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/adma.202523163"],"URL":"https:\/\/doi.org\/10.1002\/adma.202523163","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]},"assertion":[{"value":"2025-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23163"}}