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To address this challenge, inspired by the \u201cfortress effect\u201d, we report an allicin\u2010based nanoplatform of biolubrication (PPCG) that establishes a physical and biological protective barrier for precise modulation of the periodontal microenvironment. PPCG integrates hydration\u2010lubricating diblock copolymer P(DMA\u2010bMPC) (PDMPC) with bioactive allicin. The lubricating PDMPC barrier may suppress pathogenic microbial adhesion and biofilm formation, constituting an \u201couter fortress wall\u201d against bacterial invasion. Concurrently, sustained release of allicin could regulate bone marrow mesenchymal stem cells (BMMSCs) and mitigate inflammatory responses. It could preserve stemness and multipotent differentiation potential, thereby forming an \u201cinner defensive citadel\u201d that promotes soft and hard tissue regeneration. This dual protective barrier can markedly attenuate periodontal tissue senescence and inflammatory and prevent alveolar bone loss in mice periodontitis model. Furthermore, PPCG could rebalance the oral microbiota and maintain ecological homeostasis. Therapeutic efficacy is also corroborated using an artificial intelligence\u2010assisted detection system based on the YOLO v8 deep learning model. Collectively, this study presents a therapeutic intervention strategy for periodontitis, offering a scalable and translational approach for treating inflammation and senescence.<\/jats:p>","DOI":"10.1002\/adma.202523197","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:31:43Z","timestamp":1772969503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Biologically Lubricating Allicin\u2010Based Nanoplatform for Remodeling the Inflammation\u2010Senescence Axis in the Treatment of Periodontitis"],"prefix":"10.1002","volume":"38","author":[{"given":"Gengtian","family":"Sun","sequence":"first","affiliation":[{"name":"School and Hospital of Stomatology Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinuo","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical Engineering Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinna","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of General Dentistry II Peking University School and Hospital of Stomatology &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyi","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical Engineering Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanmeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Dentistry II Peking University School and Hospital of Stomatology &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Dentistry II Peking University School and Hospital of Stomatology &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of General Dentistry II Peking University School and Hospital of Stomatology &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Liu","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical Engineering Tsinghua University  Beijing China"},{"name":"Beijing Key Laboratory of Intelligent Organ Biofabrication and Regenerative Repair  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3531-6171","authenticated-orcid":false,"given":"Ludan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Dentistry II Peking University School and Hospital of Stomatology &amp; 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